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- W2806317307 abstract "Objective: Evaluate the relationship between contrast sensitivity and executive dysfunction in patients with Parkinson Disease (PD) and healthy controls (HC). Background: Progressive cognitive impairment is a common non-motor symptom in PD. This symptom negatively affects quality of life and increases caregiver burden. Executive dysfunction is one of the earliest manifestations of cognitive decline in PD. PD patients also have impaired visual contrast sensitivity (CS), likely due to dopaminergic degeneration in retinal amacrine cells. We hypothesized that contrast sensitivity would be more impaired in PD compared to HC and that these deficits would correlate with executive dysfunction. Design/Methods: We evaluated 26 PD and 30 age-and sex-matched HC participants. CS was measured with the Pelli-Robson chart. Additionally, participants were evaluated with the Montreal Cognitive Assessment (MoCA), Psychomotor Vigilance Task (PVT), Trails A and B, and Stroop color naming, word naming, inhibition (Inh), and inhibition/switching (I/S). Summary statistics were compared between groups with 2-tailed t-tests. Correlations between variables were calculated with Pearson correlation coefficients. Results: There were no significant demographic differences between PD and HC. Contrast sensitivity was significantly worse in PD participants compared to controls (p=0.008). PD participants also performed worse on measures of executive function including Trails A (p=0.014), Trails B (p=0.012), Trails B-A (p=0.004), Stroop Inh (p=0.035), and Stroop I/S (0.043) and on the PVT (p=0.025). There was no difference in MoCA between groups. Among PD participants, worse CS was significantly correlated with impaired Trails A and PVT performance. Among HC, CS was significantly correlated with MoCA, Stoop Inh, and Stroop I/S. Conclusions: PD participants had impaired CS and executive function compared to HC. In this sample, impaired contrast sensitivity in PD was not associated with most measures of executive dysfunction, but was correlated with vigilance (PVT). This indicates that there may be other, unmeasured factors that influence cognitive dysfunction in PD. Study Supported by: NIA P30 AG022838 Roybal Center NINDS K23NS080912 Disclosure: Dr. Memon has nothing to disclose. Dr. Chakrabarty has nothing to disclose. Dr. Memon has nothing to disclose. Dr. Joop has nothing to disclose. Dr. Pilkington has nothing to disclose. Dr. Wood has nothing to disclose. Dr. Amara has nothing to disclose." @default.
- W2806317307 created "2018-06-13" @default.
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- W2806317307 date "2017-04-18" @default.
- W2806317307 modified "2023-09-23" @default.
- W2806317307 title "Contrast Sensitivity and Executive Dysfunction in Parkinson Disease and Healthy Older Adults (P6.012)" @default.
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