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• W2806328629 abstract "The objective of the present work was to develop solid lipid nanoparticles (SLNs) as drug-encapsulating structures by the solvent injection method. In this report, for the first time the inherent potential of lactonic sophorolipid (glycolipid) was exploited to formulate SLNs. A range of different Pluronic copolymers were screened by dynamic and static light scattering with the aim of obtaining most stable SLNs. To comprehend the structure of the SLNs, techniques such as transmission electron microscopy, differential scanning calorimetry, Fourier transform infrared spectroscopy, and X-ray diffraction were employed. A clear correlation between the type of Pluronic and size and stability of the SLNs could be drawn. The vector properties of the formed SLNs were assessed for both the encapsulated hydrophobic drugs-rifampicin and dapsone. To elucidate the transport mechanism of drug release, kinetic modeling was carried out on the drug release profiles. The promising results of sophorolipid-based SLNs have actually established a new arena beneath the significantly developed field of SLNs." @default.
• W2806328629 created "2018-06-13" @default.
• W2806328629 creator A5029680955 @default.
• W2806328629 creator A5071721672 @default.
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• W2806328629 date "2018-06-06" @default.
• W2806328629 modified "2023-10-02" @default.
• W2806328629 title "Biomimetic Solid Lipid Nanoparticles of Sophorolipids Designed for Antileprosy Drugs" @default.
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• W2806328629 doi "https://doi.org/10.1021/acs.jpcb.8b03081" @default.
• W2806328629 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29874078" @default.
• W2806328629 hasPublicationYear "2018" @default.
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