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- W2806337145 abstract "A 7-day randomised controlled pre-clinical trial utilising an existing extremity war wound model compared the efficacy of saline soaked gauze to commercially available dressings. The Flexor Carpi Ulnaris of anaesthetised rabbits was exposed to high-energy trauma using a computer-controlled jig and inoculated with 106 Staphylococcus aureus 3 hours prior to application of dressing. Quantitative microbiological assessment demonstrated reduced bacterial counts in INADINE (Iodine) and ACTICOAT (Nanocrystalline Silver) groups and an increase in ACTIVON TULLE (Manuka Honey) group (2-way ANOVA p<0.05).Clinical observations were made throughout the study. Haematology and plasma cytokines were analysed at intervals. Post-mortem histopathology included subjective semi-quantitative assessment of pathology severity using light microscopy to grade muscle injury and lymph node activation. Tissue samples were also examined using scanning electron microscopy (SEM).There were no bacteraemias, abscesses, purulent discharge ..." @default.
- W2806337145 created "2018-06-13" @default.
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- W2806337145 date "2018-02-21" @default.
- W2806337145 modified "2023-09-26" @default.
- W2806337145 title "DETERMINING THE CLINICAL RELEVANCE OF STATISTICALLY SIGNIFICANT CHANGES IN BACTERIAL COUNTS IN A MODEL OF EXTREMITY WAR WOUNDS" @default.
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