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• W2806353596 abstract "Clinical Insights: Staphylococcus aureus Antibiotic Resistance Methicillin-resistant Staphylococcus aureus: impact on care in the neonatal unitMelissa U Nelson, Matthew J Bizzarro & Patrick G GallagherMelissa U NelsonMelissa U Nelson is a clinical fellow in the Department of Pediatrics, Division of Neonatal–Perinatal Medicine at Yale University School of Medicine (CT, USA). Her research interests include neonatal infectious disease epidemiology and quality and safety within the neonatal intensive care unit.Search for more papers by this author, Matthew J BizzarroMatthew J Bizzarro is Associate Professor in the Department of Pediatrics at Yale University School of Medicine and Medical Director of the Neonatal Intensive Care Unit at Yale-New Haven Children’s Hospital (CT, USA). His research interests include neonatal infectious disease epidemiology and hospital-acquired infections.Search for more papers by this author & Patrick G GallagherPatrick G Gallagher is Professor in the Departments of Pediatrics, Genetics and Pathology at Yale University School of Medicine. He is Director for both the Yale Center for Blood Disorders and the Expression and Genomics Core at the Yale Center of Excellence in Molecular Hematology. His research interests include neonatal hematology, erythropoiesis, inherited abnormalities of the erythrocyte, and neonatal infectious disease epidemiology.Search for more papers by this authorPublished Online:9 Jul 2014https://doi.org/10.2217/ebo.13.571AboutSectionsView ArticleView Full TextPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack Citations ShareShare onFacebookTwitterLinkedInReddit View chapterAbstract: Methicillin-resistant Staphylococcus aureus (MRSA) is a pervasive pathogen affecting premature and critically ill infants in neonatal intensive care units (NICUs) worldwide. Neonates are vulnerable to colonization and infection with MRSA, and often suffer significant morbidity and mortality as a consequence. Research exploring the epidemiology of MRSA transmission and infection in neonates has aided in determining risk factors that predispose infants to MRSA acquisition and infection. Molecular analysis of the evolution of MRSA strains has enabled improved understanding of how this bacterium has become so virulent and invasive. Increased knowledge regarding MRSA transmission and pathogenesis has led to the development of various approaches for diagnosis, prevention and treatment of MRSA in neonates. These interventions have had variable rates of success. This chapter outlines the epidemiology of MRSA colonization and infection within NICUs and highlights the importance of early detection, appropriate treatment regimens, and prevention strategies in order to reduce significant associated neonatal morbidity. References1 Jevons M . ‘Cellbenin‘-resistant staphylococci . Br. Med. J. 1 (5219) , 124 – 125 (1961) . Crossref, Google Scholar2 Gerber JS , Coffin SE , Smathers SA et al. Trends in the incidence of methicillin-resistant Staphylococcus aureus infection in children‘s hospitals in the United States . Clin. Infect. Dis. 49 (1) , 65 – 71 (2009) . 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Methicillin-resistant Staphylococcus aureus: a pervasive pathogen highlights the need for new antimicrobial development . Yale J. Biol. Med. 83 (4) , 223 – 233 (2010) . Medline, CAS, Google ScholarFiguresReferencesRelatedDetails Clinical Insights: Staphylococcus aureus Antibiotic ResistanceMetrics Downloaded 14 times History Published online 9 July 2014 Published in print July 2014 Information© Future Medicine Ltd© Future Medicine LtdPDF download" @default.
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