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- W2806359197 abstract "Summary Mammalian chromosomes are partitioned into A/B compartments and topologically associated domains (TADs). The inactive X (Xi) chromosome, however, adopts a distinct conformation without evident compartments or TADs. Here, through exploration of an architectural protein, structural-maintenance-of-chromosomes hinge domain containing 1 (SMCHD1), we probe how the Xi is reconfigured during X chromosome inactivation. A/B compartments are first fused into S1 and S2 compartments, coinciding with Xist spreading into gene-rich domains. SMCHD1 then binds S1/S2 compartments and merges them to create a compartment-less architecture. Contrary to current views, TADs remain on the Xi but in an attenuated state. Ablating SMCHD1 results in a persistent S1/S2 organization and strengthening of TADs. Furthermore, loss of SMCHD1 causes regional defects in Xist spreading and erosion of heterochromatic silencing. We present a stepwise model for Xi folding, where SMCHD1 attenuates a hidden layer of Xi architecture to facilitate Xist spreading." @default.
- W2806359197 created "2018-06-13" @default.
- W2806359197 creator A5001793565 @default.
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- W2806359197 creator A5033760439 @default.
- W2806359197 creator A5036311069 @default.
- W2806359197 creator A5076083250 @default.
- W2806359197 date "2018-07-01" @default.
- W2806359197 modified "2023-10-12" @default.
- W2806359197 title "SMCHD1 Merges Chromosome Compartments and Assists Formation of Super-Structures on the Inactive X" @default.
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- W2806359197 doi "https://doi.org/10.1016/j.cell.2018.05.007" @default.
- W2806359197 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6475921" @default.
- W2806359197 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29887375" @default.
- W2806359197 hasPublicationYear "2018" @default.
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