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• W2806365544 abstract "Astrocytomas are the most common malignant glial tumors. With improved prognosis, it is possible for patients to pursue pregnancy post-treatment. However, with potential gonadotoxicity of oncology treatments, fertility preservation prior to chemotherapy and/or radiation therapy should be considered. This requires close collaboration between the oncologist and reproductive endocrinologist. To our knowledge this is the first report of successful pregnancies following fertility preservation for AA. 33-year-old nulligravid woman with newly diagnosed anaplastic astrocytoma (AA; WHO grade III, IDH1-negative) sought fertility preservation. Prior to chemotherapy and radiation for AA, the patient underwent in vitro fertilization (IVF) for fertility preservation, resulting in 8 vitrified embryos. Following chemo-radiation, the patient underwent two rounds of frozen embryo transfers (FET), each resulting in a successful singleton pregnancy. This case illustrates the realistic possibility, in carefully selected patients with brain tumors, of oocyte or embryo cryo-preservation prior to chemo-radiation and subsequent pregnancies." @default.
• W2806365544 created "2018-06-13" @default.
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• W2806365544 date "2018-05-09" @default.
• W2806365544 modified "2023-09-25" @default.
• W2806365544 title "Two successful pregnancies following fertility preservation in a patient with anaplastic astrocytoma: a case report" @default.
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• W2806365544 doi "https://doi.org/10.1186/s12885-018-4472-9" @default.
• W2806365544 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5941593" @default.
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