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• W2806398504 abstract "Although anti-TNFα therapy is effective for treating Crohn’s disease, recently there have been cases of primary and secondary failure. There are few reports with regard to usefulness of endoscopic findings in estimating the efficacy of anti-TNFα therapy for Crohn’s disease. We explored the kinds of endoscopic findings to evaluate them in terms of their usefulness as predictors of anti-TNFα therapy efficacy for Crohn’s disease. We enrolled 56 patients with Crohn’s disease that were undergoing treatment with anti-TNFα for more than 6 months. We classified the patients into two groups: remission group (25 patients) and non-remission group (31 patients). We investigated the following parameters for comparison between the two groups: age, gender, disease site, therapeutic agents, type of anti-TNFα, time to introduction of anti-TNFα, laboratory tests (WBC, CRP, albumin), endoscopic findings (stenosis, fistula, aphtha, erosion, cobblestones, multiform ulcer, linear ulcer, and anal lesions), smoke, history of surgery, and disease activity. We analyzed the predictors of non-remission with logistic regression analysis. Statistically significance was set at p < 0.05. Non-remission rate of anti-TNFα therapy for Crohn’s disease was observed to be 55%. Age, gender, disease site, therapeutic agents, type of anti-TNFα, and laboratory tests were not different between two groups. The time to introduction of anti-TNFα in the non-remission group was significantly longer than that in remission group (88 mo. vs. 52 mo., p = 0.041). The frequencies of fistula (42% vs. 16%), linear ulcer (81% vs. 52%), and anal lesions (68% vs. 32%) were significantly higher in the non-remission group. Further, disease activity was significantly more severe in the non-remission group. Multivariate analysis revealed that the linear ulcer was the only predictor with non-remission of anti-TNFα therapy (Odds ratio 4.63, 95% confidence interval 1.01-27.6, p = 0.048). In the present study, we demonstrated that the endoscopic findings are useful as predictors of efficacy of anti-TNFα therapy for Crohn’s disease. This information would help in the development of an efficient therapeutic strategy against Crohn’s disease." @default.
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• W2806398504 date "2018-06-01" @default.
• W2806398504 modified "2023-09-23" @default.
• W2806398504 title "Su1683 ENDOSCOPIC FINDINGS ARE USEFUL AS PREDICTORS OF EFFICACY OF ANTI-TNFα THERAPY FOR CROHN'S DISEASE" @default.
• W2806398504 doi "https://doi.org/10.1016/j.gie.2018.04.1795" @default.
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