Matches in SemOpenAlex for { <https://semopenalex.org/work/W2806404703> ?p ?o ?g. }
- W2806404703 abstract "The interaction between T cell and dendritic cells (DCs) that leads to T cell activation affects the progression of the immune response including autoimmune diseases. Antigen presentation on immune cell surface, formation of an immunological synapse (IS) and specific identification of complex by T cells including two activating signals are necessary steps that lead to T cell activation. The formation of stimulatory IS involves the inclusion of costimulatory molecules, such as ICAM-1/LFA-1 and CD28/B7-1, and so on. Some fusion proteins and monoclonal antibodies targeting costimulatory molecules have been developed and approved to treat autoimmune diseases, including rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), multiple sclerosis (MS), type I diabetes (T1D), inflammatory bowel disease (IBD), and psoriasis. These biological agents, including CTLA-4- and LFA-3-Ig, anti-CD3 monoclonal antibody, could prevent the successful engagement of DCs by T cell with significant efficacy and safety profile. In this article, we reviewed the molecular mechanisms of T cell activation during the interaction between T cells and DCs, and summarized some biological agents that target costimulatory molecules involved in the regulation of T cell activation." @default.
- W2806404703 created "2018-06-13" @default.
- W2806404703 creator A5003799076 @default.
- W2806404703 creator A5030383311 @default.
- W2806404703 creator A5039678565 @default.
- W2806404703 creator A5041143430 @default.
- W2806404703 creator A5072802017 @default.
- W2806404703 date "2018-06-26" @default.
- W2806404703 modified "2023-10-14" @default.
- W2806404703 title "Molecular Mechanisms of T Cells Activation by Dendritic Cells in Autoimmune Diseases" @default.
- W2806404703 cites W1030189739 @default.
- W2806404703 cites W1536006864 @default.
- W2806404703 cites W1557823695 @default.
- W2806404703 cites W1584075206 @default.
- W2806404703 cites W1590271256 @default.
- W2806404703 cites W1630171124 @default.
- W2806404703 cites W1639524701 @default.
- W2806404703 cites W1750613264 @default.
- W2806404703 cites W1763258797 @default.
- W2806404703 cites W1848243976 @default.
- W2806404703 cites W1850648379 @default.
- W2806404703 cites W1855822212 @default.
- W2806404703 cites W1965165794 @default.
- W2806404703 cites W1970971642 @default.
- W2806404703 cites W1971522146 @default.
- W2806404703 cites W1972871744 @default.
- W2806404703 cites W1973177425 @default.
- W2806404703 cites W1975592271 @default.
- W2806404703 cites W1980358710 @default.
- W2806404703 cites W1983635410 @default.
- W2806404703 cites W1986722574 @default.
- W2806404703 cites W1988573003 @default.
- W2806404703 cites W1993292630 @default.
- W2806404703 cites W2007920860 @default.
- W2806404703 cites W2015095309 @default.
- W2806404703 cites W2015876690 @default.
- W2806404703 cites W2016055373 @default.
- W2806404703 cites W2020384794 @default.
- W2806404703 cites W2022599580 @default.
- W2806404703 cites W2023276714 @default.
- W2806404703 cites W2023930071 @default.
- W2806404703 cites W2024387258 @default.
- W2806404703 cites W2025137918 @default.
- W2806404703 cites W2027674121 @default.
- W2806404703 cites W2028968136 @default.
- W2806404703 cites W2032218738 @default.
- W2806404703 cites W2042126924 @default.
- W2806404703 cites W2046897800 @default.
- W2806404703 cites W2049506809 @default.
- W2806404703 cites W2050151794 @default.
- W2806404703 cites W2056088597 @default.
- W2806404703 cites W2061071534 @default.
- W2806404703 cites W2062453785 @default.
- W2806404703 cites W2064539458 @default.
- W2806404703 cites W2064882706 @default.
- W2806404703 cites W2066234762 @default.
- W2806404703 cites W2070576765 @default.
- W2806404703 cites W2073621589 @default.
- W2806404703 cites W2073791328 @default.
- W2806404703 cites W2075723649 @default.
- W2806404703 cites W2077215378 @default.
- W2806404703 cites W2077904168 @default.
- W2806404703 cites W2079359234 @default.
- W2806404703 cites W2085332498 @default.
- W2806404703 cites W2091992513 @default.
- W2806404703 cites W2094461303 @default.
- W2806404703 cites W2095017027 @default.
- W2806404703 cites W2095091491 @default.
- W2806404703 cites W2098005365 @default.
- W2806404703 cites W2102013854 @default.
- W2806404703 cites W2102133058 @default.
- W2806404703 cites W2106218189 @default.
- W2806404703 cites W2106880687 @default.
- W2806404703 cites W2112239380 @default.
- W2806404703 cites W2112830170 @default.
- W2806404703 cites W2112844656 @default.
- W2806404703 cites W2115359896 @default.
- W2806404703 cites W2118175246 @default.
- W2806404703 cites W2120106378 @default.
- W2806404703 cites W2124670599 @default.
- W2806404703 cites W2126873850 @default.
- W2806404703 cites W2128395874 @default.
- W2806404703 cites W2130506153 @default.
- W2806404703 cites W2140025019 @default.
- W2806404703 cites W2140213275 @default.
- W2806404703 cites W2143105454 @default.
- W2806404703 cites W2143772132 @default.
- W2806404703 cites W2143783687 @default.
- W2806404703 cites W2147662720 @default.
- W2806404703 cites W2148774610 @default.
- W2806404703 cites W2149513114 @default.
- W2806404703 cites W2150780552 @default.
- W2806404703 cites W2151271464 @default.
- W2806404703 cites W2152696606 @default.
- W2806404703 cites W2153450401 @default.
- W2806404703 cites W2157800695 @default.
- W2806404703 cites W2159351533 @default.
- W2806404703 cites W2162540156 @default.
- W2806404703 cites W2169339649 @default.
- W2806404703 cites W2170720046 @default.