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• W2806422799 abstract "Zika virus (ZIKV) is a flavivirus that is highly neurotropic causing congenital abnormalities and neurological damage to the central nervous systems (CNS). In this study, we used a human induced pluripotent stem cell (iPSC)-derived blood brain barrier (BBB) model to demonstrate that ZIKV can infect brain endothelial cells (i-BECs) without compromising the BBB barrier integrity or permeability. Although no disruption to the BBB was observed post-infection, ZIKV particles were released on the abluminal side of the BBB model and infected underlying iPSC-derived neural progenitor cells (i-NPs). AXL, a putative ZIKV cellular entry receptor, was also highly expressed in ZIKV-susceptible i-BEC and i-NPs. This iPSC-derived BBB model can help elucidate the mechanism by which ZIKV can infect BECs, cross the BBB and gain access to the CNS." @default.
• W2806422799 created "2018-06-13" @default.
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• W2806422799 date "2018-05-15" @default.
• W2806422799 modified "2023-10-16" @default.
• W2806422799 title "Zika virus crosses an in vitro human blood brain barrier model" @default.
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• W2806422799 doi "https://doi.org/10.1186/s12987-018-0100-y" @default.
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