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- W2806435963 abstract "Abstract Animals living at high altitudes have evolved distinct phenotypic and genotypic adaptations against stressful environments. We studied the adaptive patterns of altitudinal stresses on transcriptome turnover in subterranean plateau zokors ( Myospalax baileyi ) in the high-altitude Qinghai-Tibetan Plateau. Transcriptomes of zokors from three populations with distinct altitudes and ecologies ( L ow: 2846 m, M iddle: 3282 m, H igh: 3,714 m) were sequenced and compared. Phylogenetic and principal component analyses classified them into three divergent altitudinal population clusters. Genetic polymorphisms showed that the population at H , approaching the uppermost species boundary, harbors the highest genetic polymorphism. Moreover, 1056 highly up-regulated UniGenes were identified from M to H . Gene ontologies reveal genes like EPAS1 and COX1 were overexpressed under hypoxia conditions. EPAS1 , EGLN1 , and COX1 were convergent in high-altitude adaptation against stresses in other species. The fixation indices ( F ST and G ST )-based outlier analysis identified 191 and 211 genes, highly differentiated among L , M , and H . We observed adaptive transcriptome changes in Myospalax baileyi , across a few hundred meters, near the uppermost species boundary, regardless of their relatively stable underground burrows’ microclimate. The highly variant genes identified in Myospalax were involved in hypoxia tolerance, hypercapnia tolerance, ATP-pathway energetics, and temperature changes." @default.
- W2806435963 created "2018-06-13" @default.
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- W2806435963 date "2018-03-16" @default.
- W2806435963 modified "2023-10-16" @default.
- W2806435963 title "Adaptive Transcriptome Profiling of Subterranean Zokor, Myospalax baileyi, to High- Altitude Stresses in Tibet" @default.
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- W2806435963 doi "https://doi.org/10.1038/s41598-018-22483-7" @default.
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