FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2806444128> ?p ?o ?g. }

• W2806444128 endingPage "840" @default.
• W2806444128 startingPage "833" @default.
• W2806444128 abstract "Although curcumin was widely applied as a functional food for different diseases, it was found to reduce serum testosterone level and fertility in male animals by unknown molecular mechanisms. Here in our study, we investigated the possible mechanisms of curcumin-suppressed testosterone production in Leydig cells. Our enzyme immunoassay results showed that curcumin cell-autonomously suppressed ovine luteinizing hormone-stimulated testosterone production in primary Leydig cells and 8-bromo-cyclic adenosine monophosphate (8-br-cAMP)-induced progesterone production in MA-10 cells. Furthermore, our real-time PCR, Western blot, and 22R-OHC/pregnenolone supplementing experiment data demonstrated that curcumin suppressed 8-br-cAMP-induced steroidogenesis in Leydig cells by inhibiting the expression of StAR and Cyp11a1. Interestingly, our Western blot data showed that although curcumin suppressed PKA activity, it did not alter the 8-br-cAMP-induced phosphorylation of CREB. On the contrary, the real-time PCR results showed that curcumin suppressed 8-br-cAMP-induced expression of Nr5a1 and Fos, which are crucial for cAMP-stimulated StAR and Cyp11a1 expression in Leydig cells. Collectively, our data demonstrated that curcumin may suppress cAMP-induced steroidogenesis in mouse Leydig cells by down-regulating Nr5a1/Fos-controlled StAR and Cyp11a1 expression independently of the PKA-CREB signaling pathway." @default.
• W2806444128 created "2018-06-13" @default.
• W2806444128 creator A5003007558 @default.
• W2806444128 creator A5014542566 @default.
• W2806444128 creator A5048284973 @default.
• W2806444128 creator A5056723874 @default.
• W2806444128 date "2018-01-01" @default.
• W2806444128 modified "2023-10-01" @default.
• W2806444128 title "Curcumin downregulates 8-br-cAMP-induced steroidogenesis in mouse Leydig cells by suppressing the expression of Cyp11a1 and StAR independently of the PKA-CREB pathway" @default.
• W2806444128 cites W1490652408 @default.
• W2806444128 cites W1560653098 @default.
• W2806444128 cites W1610204701 @default.
• W2806444128 cites W1974103027 @default.
• W2806444128 cites W1997076062 @default.
• W2806444128 cites W2013072433 @default.
• W2806444128 cites W2019241297 @default.
• W2806444128 cites W2028242823 @default.
• W2806444128 cites W2033707220 @default.
• W2806444128 cites W2043232583 @default.
• W2806444128 cites W2045336410 @default.
• W2806444128 cites W2057884941 @default.
• W2806444128 cites W2074622933 @default.
• W2806444128 cites W2075237097 @default.
• W2806444128 cites W2081491101 @default.
• W2806444128 cites W2083658917 @default.
• W2806444128 cites W2097852397 @default.
• W2806444128 cites W2113508608 @default.
• W2806444128 cites W2115158038 @default.
• W2806444128 cites W2115470553 @default.
• W2806444128 cites W2119627494 @default.
• W2806444128 cites W2126846194 @default.
• W2806444128 cites W2167144241 @default.
• W2806444128 cites W2168007569 @default.
• W2806444128 cites W2169238639 @default.
• W2806444128 cites W2315388725 @default.
• W2806444128 doi "https://doi.org/10.1507/endocrj.ej18-0010" @default.
• W2806444128 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29887570" @default.
• W2806444128 hasPublicationYear "2018" @default.
• W2806444128 type Work @default.
• W2806444128 sameAs 2806444128 @default.
• W2806444128 citedByCount "11" @default.
• W2806444128 countsByYear W28064441282019 @default.
• W2806444128 countsByYear W28064441282020 @default.
• W2806444128 countsByYear W28064441282021 @default.
• W2806444128 countsByYear W28064441282022 @default.
• W2806444128 countsByYear W28064441282023 @default.
• W2806444128 crossrefType "journal-article" @default.
• W2806444128 hasAuthorship W2806444128A5003007558 @default.
• W2806444128 hasAuthorship W2806444128A5014542566 @default.
• W2806444128 hasAuthorship W2806444128A5048284973 @default.
• W2806444128 hasAuthorship W2806444128A5056723874 @default.
• W2806444128 hasBestOaLocation W28064441281 @default.
• W2806444128 hasConcept C104317684 @default.
• W2806444128 hasConcept C126322002 @default.
• W2806444128 hasConcept C134018914 @default.
• W2806444128 hasConcept C150194340 @default.
• W2806444128 hasConcept C1629964 @default.
• W2806444128 hasConcept C170493617 @default.
• W2806444128 hasConcept C185592680 @default.
• W2806444128 hasConcept C2775948956 @default.
• W2806444128 hasConcept C2776415932 @default.
• W2806444128 hasConcept C2776668983 @default.
• W2806444128 hasConcept C2777736315 @default.
• W2806444128 hasConcept C2778250585 @default.
• W2806444128 hasConcept C2778575703 @default.
• W2806444128 hasConcept C2779279991 @default.
• W2806444128 hasConcept C2779670467 @default.
• W2806444128 hasConcept C2780193516 @default.
• W2806444128 hasConcept C2780902042 @default.
• W2806444128 hasConcept C526171541 @default.
• W2806444128 hasConcept C55493867 @default.
• W2806444128 hasConcept C62231903 @default.
• W2806444128 hasConcept C71315377 @default.
• W2806444128 hasConcept C71924100 @default.
• W2806444128 hasConcept C80446465 @default.
• W2806444128 hasConcept C86339819 @default.
• W2806444128 hasConcept C86803240 @default.
• W2806444128 hasConceptScore W2806444128C104317684 @default.
• W2806444128 hasConceptScore W2806444128C126322002 @default.
• W2806444128 hasConceptScore W2806444128C134018914 @default.
• W2806444128 hasConceptScore W2806444128C150194340 @default.
• W2806444128 hasConceptScore W2806444128C1629964 @default.
• W2806444128 hasConceptScore W2806444128C170493617 @default.
• W2806444128 hasConceptScore W2806444128C185592680 @default.
• W2806444128 hasConceptScore W2806444128C2775948956 @default.
• W2806444128 hasConceptScore W2806444128C2776415932 @default.
• W2806444128 hasConceptScore W2806444128C2776668983 @default.
• W2806444128 hasConceptScore W2806444128C2777736315 @default.
• W2806444128 hasConceptScore W2806444128C2778250585 @default.
• W2806444128 hasConceptScore W2806444128C2778575703 @default.
• W2806444128 hasConceptScore W2806444128C2779279991 @default.
• W2806444128 hasConceptScore W2806444128C2779670467 @default.
• W2806444128 hasConceptScore W2806444128C2780193516 @default.
• W2806444128 hasConceptScore W2806444128C2780902042 @default.
• W2806444128 hasConceptScore W2806444128C526171541 @default.
• W2806444128 hasConceptScore W2806444128C55493867 @default.
• W2806444128 hasConceptScore W2806444128C62231903 @default.
• W2806444128 hasConceptScore W2806444128C71315377 @default.

• next