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• W2806474053 abstract "Novel bacterial type II topoisomerase inhibitors (NBTIs) constitute a promising new class of antibacterial agents. We report a series of NBTIs with potent anti-staphylococcal activity and diminished hERG inhibition. Dioxane-linked compound 9 demonstrated MICs ≤1 μg/mL against both methicillin-susceptible (MSSA) and -resistant Staphylococcus aureus (MRSA), accompanied by reduced hERG inhibition as compared to cyclohexane- or piperidine-linked analogs." @default.
• W2806474053 created "2018-06-13" @default.
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• W2806474053 date "2018-08-01" @default.
• W2806474053 modified "2023-09-23" @default.
• W2806474053 title "Synthesis and anti-staphylococcal activity of novel bacterial topoisomerase inhibitors with a 5-amino-1,3-dioxane linker moiety" @default.
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• W2806474053 doi "https://doi.org/10.1016/j.bmcl.2018.06.003" @default.
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