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- W2806478275 abstract "The nonsteroidal anti-inflammatory agent aspirin is widely used for preventing and treating cardiovascular and cerebrovascular diseases. In addition, epidemiologic evidences reveal that aspirin may prevent a variety of human cancers, while data on the association between aspirin and some kinds of cancer are conflicting. Preclinical studies and clinical trials also reveal the therapeutic effect of aspirin on cancer. Although cyclooxygenase is a well-known target of aspirin, recent studies uncover other targets of aspirin and its metabolites, such as AMP-activated protein kinase, cyclin-dependent kinase, heparanase, and histone. Accumulating evidence demonstrate that aspirin may act in different cell types, such as epithelial cell, tumor cell, endothelial cell, platelet, and immune cell. Therefore, aspirin acts on diverse hallmarks of cancer, such as sustained tumor growth, metastasis, angiogenesis, inflammation, and immune evasion. In this review, we focus on recent progress in the use of aspirin for cancer chemoprevention and therapy, and integratively analyze the mechanisms underlying the anticancer effects of aspirin and its metabolites. We also discuss mechanisms of aspirin resistance and describe some derivatives of aspirin, which aim to overcome the adverse effects of aspirin." @default.
- W2806478275 created "2018-06-13" @default.
- W2806478275 creator A5001487848 @default.
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- W2806478275 date "2018-06-01" @default.
- W2806478275 modified "2023-10-17" @default.
- W2806478275 title "Complex roles of the old drug aspirin in cancer chemoprevention and therapy" @default.
- W2806478275 cites W1018267401 @default.
- W2806478275 cites W1092939784 @default.
- W2806478275 cites W1506244410 @default.
- W2806478275 cites W1519299874 @default.
- W2806478275 cites W1522760404 @default.
- W2806478275 cites W1572834204 @default.
- W2806478275 cites W1586708178 @default.
- W2806478275 cites W1591869705 @default.
- W2806478275 cites W1597471160 @default.
- W2806478275 cites W1659996343 @default.
- W2806478275 cites W1919616221 @default.
- W2806478275 cites W1944222786 @default.
- W2806478275 cites W1963677987 @default.
- W2806478275 cites W1964514956 @default.
- W2806478275 cites W1964552652 @default.
- W2806478275 cites W1964653907 @default.
- W2806478275 cites W1965809235 @default.
- W2806478275 cites W1968687302 @default.
- W2806478275 cites W1975459165 @default.
- W2806478275 cites W1977632740 @default.
- W2806478275 cites W1985452613 @default.
- W2806478275 cites W1987053951 @default.
- W2806478275 cites W1987698903 @default.
- W2806478275 cites W1988883597 @default.
- W2806478275 cites W1991460649 @default.
- W2806478275 cites W1991612914 @default.
- W2806478275 cites W1995553410 @default.
- W2806478275 cites W1995868967 @default.
- W2806478275 cites W1996493257 @default.
- W2806478275 cites W1997343401 @default.
- W2806478275 cites W1997799520 @default.
- W2806478275 cites W1997877243 @default.
- W2806478275 cites W1998042325 @default.
- W2806478275 cites W1998204523 @default.
- W2806478275 cites W1999208772 @default.
- W2806478275 cites W1999571408 @default.
- W2806478275 cites W2001953141 @default.
- W2806478275 cites W2002404925 @default.
- W2806478275 cites W2004927543 @default.
- W2806478275 cites W2005930773 @default.
- W2806478275 cites W2006483529 @default.
- W2806478275 cites W2007251848 @default.
- W2806478275 cites W2008617419 @default.
- W2806478275 cites W2009132110 @default.
- W2806478275 cites W2011106612 @default.
- W2806478275 cites W2011863243 @default.
- W2806478275 cites W2016390566 @default.
- W2806478275 cites W2017514786 @default.
- W2806478275 cites W2019274138 @default.
- W2806478275 cites W2021654829 @default.
- W2806478275 cites W2027560916 @default.
- W2806478275 cites W2028589365 @default.
- W2806478275 cites W2029857102 @default.
- W2806478275 cites W2032391746 @default.
- W2806478275 cites W2033644031 @default.
- W2806478275 cites W2035739677 @default.
- W2806478275 cites W2036148750 @default.
- W2806478275 cites W2038733728 @default.
- W2806478275 cites W2041765569 @default.
- W2806478275 cites W2043666180 @default.
- W2806478275 cites W2043854938 @default.
- W2806478275 cites W2044692830 @default.
- W2806478275 cites W2044730581 @default.
- W2806478275 cites W2047361362 @default.
- W2806478275 cites W2049656151 @default.
- W2806478275 cites W2050650884 @default.
- W2806478275 cites W2051700726 @default.
- W2806478275 cites W2051890972 @default.
- W2806478275 cites W2052048865 @default.
- W2806478275 cites W2056095609 @default.
- W2806478275 cites W2069830525 @default.
- W2806478275 cites W2071975518 @default.
- W2806478275 cites W2071988543 @default.
- W2806478275 cites W2073675064 @default.
- W2806478275 cites W2081410358 @default.
- W2806478275 cites W2082035590 @default.
- W2806478275 cites W2084730518 @default.
- W2806478275 cites W2085388752 @default.
- W2806478275 cites W2085768428 @default.
- W2806478275 cites W2089330652 @default.
- W2806478275 cites W2098779170 @default.
- W2806478275 cites W2098964407 @default.
- W2806478275 cites W2102937816 @default.
- W2806478275 cites W2104236657 @default.
- W2806478275 cites W2106285227 @default.
- W2806478275 cites W2107601538 @default.
- W2806478275 cites W2107822490 @default.
- W2806478275 cites W2108376372 @default.