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• W2806483502 abstract "BioTechniquesVol. 37, No. 3 ScientistsOpen AccessProfile of Robert G. RoederArnold and Mabel Beckman Professor, Head of the Laboratory of Biochemistry and Molecular Biology, The Rockefeller UniversityLaura BonettaLaura BonettaSearch for more papers by this authorPublished Online:6 Jun 2018https://doi.org/10.2144/04373SP01AboutSectionsPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack Citations ShareShare onFacebookTwitterLinkedInRedditEmail Hard at WorkI had nightmares about sea urchins for several years after my thesis work. A small change in the environment can cause these animals to spawn or die. Many times I would go to the lab to collect eggs and sperm for a new experiment only to find that all the sea urchins had had a massive communal orgasm, and I had nothing to work with.I thought the sea urchin would make a good model organism to study eukaryotic RNA synthesis during development. I had not realized I would spend so much of my time taking care of the organism itself. Nonetheless, it turned out to be an excellent choice.Having to collect the animals gave me a forced opportunity to get out of the lab and head for the Strait of Juan de Fuca several times a year. More importantly, I was able to detect the trio of eukaryotic RNA polymerases. All three were fairly abundant in the nuclei of sea urchin embryos. I was excited about the discovery because, until then, the field of eukaryotic transcription had been in the dark ages. The 1969 Nature paper that we published—my first—received more reprint requests than any other paper I've published since.I had known I wanted to work on RNA synthesis since taking an undergraduate biochemistry course during my senior year at Wabash College, a men's liberal arts college in Crawfordsville, IN. The lectures on the regulation of bacterial gene expression caught my attention and put an end to my plans of attending medical school. I joined the laboratory of Bill Rutter, who was then at the University of Illinois, for my Ph.D. Rutter was an enzymologist, but he wanted to enter the gene expression field. I was the guinea pig to get that project started. When Rutter moved to the University of Washington in Seattle, there were several other groups interested in RNA synthesis.Rutter gave people a lot of freedom. He selected people for his lab who were resourceful, ambitious, and could work on their own. I run my lab in a similar fashion in that respect. I select people based on their own qualities and let them choose what they want to work on, as long as the project fits in with my major area of interest. I don't usually micromanage projects, in part because I like to challenge people to become independent thinkers and prepare them for a career in science. My lab is definitely a testing ground.Regrettably, I don't work at the bench anymore. I work the telephone and do the writing instead. I am a fairly shy individual. I went into science partly because I thought I could avoid public speaking, writing, and social interactions. Of course now I know these things are critical for success, so I take them in stride. But I do miss the bench.My father thought I had no business in higher education. He was a farmer and did everything he could to keep his three sons on the farm. My parents were of German descent and were very conservative and industrious. I probably got my work ethic from them.While attending high schools in Boonville and Jasper, IN, I had to work on the farm. I also worked at a supermarket to make money to pay for college. I was studious, probably beyond what was necessary, but wanted to keep up my grades. In fact, I remember not taking a couple of classes for fear that they would tarnish my record. One of them was typing and the other was speech—both are problems to this day.I have always worked harder than I would have wanted, and even now there are many demands on my time. I recently started a new family and have a 2-year-old daughter. I love this stage in her life and do spend time with her. I wish I could relive this period with my two older children, because when they were this age, I was an assistant professor at Washington University Medical School in the department of Biological Chemistry headed by Roy Vagelos. I was very concerned with doing well at my job. Many people had started to engage in similar studies as us, and it was a challenge to continue to do pioneering work in the field. But it was great fun too.Aside from science, I always wanted to do ceramics. I guess it's my way of getting back to the earth of my father's farm. During one of my many trips to Japan, I met a famous potter living in a 300-year-old farmhouse. He allowed me to work in his studio and told me that I have a talent for working with clay. I had never done it before. I have yet to take a sabbatical. Maybe I will do one at the wheel, rather than the bench.FiguresReferencesRelatedDetails Vol. 37, No. 3 Follow us on social media for the latest updates Metrics Downloaded 169 times History Published online 6 June 2018 Published in print September 2004 Information© 2004 Author(s)PDF download" @default.
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