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• W2806484899 abstract "Abstract At present, it remains poorly understood how the olfactory neuron migrates through the thick neuroepithelium during its maturation from a stem cell and how it develops a specific sensitivity to environmental odorants after maturation. We investigated the cytochemical features associated with the development of olfactory cells before and after the incorporation of dendrites into the surface of the olfactory epithelium. Using cytochemical staining for the actin cytoskeleton and other cell components, we found that immature neurons acquire a streamlined shape that resembles a «hot-dog» during their migration: a dense layer of actin microfilaments forms beneath the surface membrane of the growing dendrite, and the bulk of the nuclear material moves inside this layer. We have found that when the cell makes contact with its environment, the dendritic terminal develops a wide actin layer, inside which a pore is formed. It is assumed that the functional receptors of odorants generate across this pore the first intracellular signal from environmental water-soluble odorants. These data illustrate the important role of the cytoskeleton in the differentiation of olfactory cells." @default.
• W2806484899 created "2018-06-13" @default.
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• W2806484899 date "2018-02-27" @default.
• W2806484899 modified "2023-10-15" @default.
• W2806484899 title "Rearrangement of Actin Microfilaments in the Development of Olfactory Receptor Cells in Fish" @default.
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• W2806484899 doi "https://doi.org/10.1038/s41598-018-22049-7" @default.
• W2806484899 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5829147" @default.
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• W2806484899 hasPublicationYear "2018" @default.
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