FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2806486228> ?p ?o ?g. }

• W2806486228 abstract "Abstract This study evaluates the therapeutic potential of intranasal insulin (INI) in dexamethasone-induced insulin resistance in Wistar rats. In the first phase of the study, thirteen, healthy, untreated male Wistar rats were divided into 2 groups and administered either vehicle (0.9% Normal saline, 20 µl) or insulin (2 IU) intranasally to assess intranasal delivery of insulin in brain. In the second phase of experiments, to evaluate the acute effects of intranasal insulin on peripheral blood glucose, intranasal or intraperitoneal insulin was co-administered with or without dexamethasone 10 mg/kg to 26 male Wistar rats and blood glucose monitored. To evaluate effect of intranasal insulin in peripheral metabolic disease model, insulin or vehicle was administered via intranasal or intraperitoneal (IP) route to control or dexamethasone (Dex)-treated (0.5 mg/kg, IP) female Wistar rats for seven consecutive days. Twenty-four hours after last dose, trunk blood was collected via cardiac puncture. Biochemical assay of glucose, lipid and insulin was performed on serum while enzyme activity – glucokinase and glucose-6-phosphatase (G6Pase) or lactate dehydrogenase (LDH) and glucose-6-phosphate dehydrogenase (G6PDH) were assayed from liver and brain homogenates respectively. Acute intranasal but not intraperitoneal insulin elevated brain insulin after 30 min. In animals administered single dose of 10 mg/kg dexamethasone, intranasal and intraperitoneal insulin lowered blood glucose within one hour. However, only the former’s effect was maintained at the 3rd and fourth hour. Dex-induced hyperglycemia was associated with increased hepatic glucose-6-phosphatase activity and decreased high-density lipoprotein (HDL), these effect were attenuated by subchronic (INI) administration. Also INI did not induce oxidative stress in the brain which suggests no brain damage during the period of study. Subchronic administration of INI was able to reduce the effect of Dex-induced hyperglycemia that is associated with increased hepatic glucose-6-phosphatase activity and decreased high-density lipoprotein (HDL) without damage to the brain. We demonstrate the potential of brain targeting with intranasal insulin in a rat model of insulin resistance and peripheral metabolic disease." @default.
• W2806486228 created "2018-06-13" @default.
• W2806486228 creator A5001388233 @default.
• W2806486228 creator A5007309438 @default.
• W2806486228 creator A5021188049 @default.
• W2806486228 creator A5048622862 @default.
• W2806486228 creator A5072463477 @default.
• W2806486228 creator A5080569667 @default.
• W2806486228 creator A5083272197 @default.
• W2806486228 date "2018-12-01" @default.
• W2806486228 modified "2023-09-24" @default.
• W2806486228 title "Effect of intranasal insulin on peripheral glucose profile in dexamethasone-induced insulin resistance in Wistar rats" @default.
• W2806486228 cites W1561443084 @default.
• W2806486228 cites W1599884739 @default.
• W2806486228 cites W1964532167 @default.
• W2806486228 cites W1967964480 @default.
• W2806486228 cites W1968065358 @default.
• W2806486228 cites W1970779072 @default.
• W2806486228 cites W1973385255 @default.
• W2806486228 cites W1974581121 @default.
• W2806486228 cites W1985141707 @default.
• W2806486228 cites W2000772129 @default.
• W2806486228 cites W2004325493 @default.
• W2806486228 cites W2011430246 @default.
• W2806486228 cites W2019170686 @default.
• W2806486228 cites W2041562324 @default.
• W2806486228 cites W2047173091 @default.
• W2806486228 cites W2052688891 @default.
• W2806486228 cites W2059944224 @default.
• W2806486228 cites W2065143170 @default.
• W2806486228 cites W2065897200 @default.
• W2806486228 cites W2074479414 @default.
• W2806486228 cites W2081176248 @default.
• W2806486228 cites W2086190854 @default.
• W2806486228 cites W2089541211 @default.
• W2806486228 cites W2095249517 @default.
• W2806486228 cites W2098705100 @default.
• W2806486228 cites W2099512544 @default.
• W2806486228 cites W2116479667 @default.
• W2806486228 cites W2117674127 @default.
• W2806486228 cites W2124783702 @default.
• W2806486228 cites W2128797808 @default.
• W2806486228 cites W2135591161 @default.
• W2806486228 cites W2156600347 @default.
• W2806486228 cites W2157247104 @default.
• W2806486228 cites W2168921195 @default.
• W2806486228 cites W2229745623 @default.
• W2806486228 cites W2311774427 @default.
• W2806486228 cites W2501462863 @default.
• W2806486228 cites W2531062701 @default.
• W2806486228 cites W2602081862 @default.
• W2806486228 cites W2776146933 @default.
• W2806486228 doi "https://doi.org/10.1016/j.bjbas.2018.06.003" @default.
• W2806486228 hasPublicationYear "2018" @default.
• W2806486228 type Work @default.
• W2806486228 sameAs 2806486228 @default.
• W2806486228 citedByCount "1" @default.
• W2806486228 countsByYear W28064862282021 @default.
• W2806486228 crossrefType "journal-article" @default.
• W2806486228 hasAuthorship W2806486228A5001388233 @default.
• W2806486228 hasAuthorship W2806486228A5007309438 @default.
• W2806486228 hasAuthorship W2806486228A5021188049 @default.
• W2806486228 hasAuthorship W2806486228A5048622862 @default.
• W2806486228 hasAuthorship W2806486228A5072463477 @default.
• W2806486228 hasAuthorship W2806486228A5080569667 @default.
• W2806486228 hasAuthorship W2806486228A5083272197 @default.
• W2806486228 hasBestOaLocation W28064862281 @default.
• W2806486228 hasConcept C126322002 @default.
• W2806486228 hasConcept C134018914 @default.
• W2806486228 hasConcept C2777391703 @default.
• W2806486228 hasConcept C2779306644 @default.
• W2806486228 hasConcept C2780401358 @default.
• W2806486228 hasConcept C71924100 @default.
• W2806486228 hasConcept C85663871 @default.
• W2806486228 hasConcept C98274493 @default.
• W2806486228 hasConceptScore W2806486228C126322002 @default.
• W2806486228 hasConceptScore W2806486228C134018914 @default.
• W2806486228 hasConceptScore W2806486228C2777391703 @default.
• W2806486228 hasConceptScore W2806486228C2779306644 @default.
• W2806486228 hasConceptScore W2806486228C2780401358 @default.
• W2806486228 hasConceptScore W2806486228C71924100 @default.
• W2806486228 hasConceptScore W2806486228C85663871 @default.
• W2806486228 hasConceptScore W2806486228C98274493 @default.
• W2806486228 hasLocation W28064862281 @default.
• W2806486228 hasOpenAccess W2806486228 @default.
• W2806486228 hasPrimaryLocation W28064862281 @default.
• W2806486228 hasRelatedWork W138803513 @default.
• W2806486228 hasRelatedWork W1983709201 @default.
• W2806486228 hasRelatedWork W1986132654 @default.
• W2806486228 hasRelatedWork W2010140898 @default.
• W2806486228 hasRelatedWork W2022551048 @default.
• W2806486228 hasRelatedWork W2032225465 @default.
• W2806486228 hasRelatedWork W2065284668 @default.
• W2806486228 hasRelatedWork W2111784701 @default.
• W2806486228 hasRelatedWork W2375386793 @default.
• W2806486228 hasRelatedWork W2378290744 @default.
• W2806486228 isParatext "false" @default.
• W2806486228 isRetracted "false" @default.
• W2806486228 magId "2806486228" @default.
• W2806486228 workType "article" @default.