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- W2806497867 endingPage "105" @default.
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- W2806497867 abstract "Abstract Prepulse inhibition (PPI) of acoustic startle reflex is a well-established behavior paradigm to measure sensorimotor gating deficits. PPI is disrupted in several neuropsychiatric disorders, including schizophrenia. PPI tests can be used to screen new drugs for treatment of such disorders. In this review, we discuss how PPI paradigm can help in screening the therapeutic effects of cannabidiol (CBD). We look into recent literature about CBD effects on PPI response in animal models, especially in nonhuman primates. CBD has been shown to modify PPI in N -methyl d -aspartate receptor antagonist models for schizophrenia, both in rodents and in nonhuman primates. These results show CBD as a potential drug for the treatment of neurologic disorders that present alterations in sensorimotor system, such as schizophrenia. Moreover, the PPI paradigm seems to be a useful and relative simple paradigm to test the efficacy of CBD as a potential therapeutic drug." @default.
- W2806497867 created "2018-06-13" @default.
- W2806497867 creator A5008663002 @default.
- W2806497867 creator A5069492430 @default.
- W2806497867 date "2018-12-19" @default.
- W2806497867 modified "2023-09-25" @default.
- W2806497867 title "Cannabidiol effects on prepulse inhibition in nonhuman primates" @default.
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