FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2806500511> ?p ?o ?g. }

• W2806500511 endingPage "e33" @default.
• W2806500511 startingPage "e32" @default.
• W2806500511 abstract "To the Editor We read with interest the report by Behmenburg et al1 describing the influence of baseline anesthesia on remote ischemic preconditioning (RIPC) in rat hearts in situ. RIPC was produced by 4 cycles of 5 minutes of limb occlusion, interspersed with 5 minutes of reperfusion before a prolonged (25 minutes) left anterior descending coronary artery occlusion and 2 hours of reperfusion.1 RIPC decreased myocardial infarct size (triphenyltetrazolium chloride staining) during pentobarbital or sevoflurane–remifentanil anesthesia, but not when a propofol–remifentanil anesthetic technique was used. The findings provided further evidence that propofol inhibits, whereas sevoflurane preserves, myocardial protection afforded by RIPC. Reductions in troponin I release produced by RIPC were previously shown to occur only during isoflurane–sufentanil but not propofol–sufentanil anesthesia in patients undergoing coronary artery surgery,2 most likely because propofol inhibits activation of signal transducer and activator of transcription 5 (STAT5),3 a critical mediator of RIPC-induced protection against ischemic injury in human myocardium.4 It is noteworthy that STAT5 activation also mediates classical ischemic preconditioning.4 Whether STAT5 activation is also involved in volatile anesthetic-induced preconditioning is unknown, but this assertion seems likely because ischemic preconditioning and anesthetic-induced preconditioning share virtually indistinguishable intracellular mechanisms. From our perspective, the current and previous results are particularly interesting because they may provide an additional explanation for differences in cardiovascular outcome between volatile- and propofol-based anesthetic techniques in patients undergoing cardiac surgery.4 Several clinical trials and a number of meta-analyses showed that the use of a volatile anesthetic decreases myocardial necrosis and preserves left ventricular function compared with propofol-based anesthesia in cardiac surgery patients. These findings were interpreted as clinical evidence for volatile anesthetic-induced myocardial protection, providing a rationale for the use of volatile anesthetics in these patients.4 The current results by Behmenburg et al1 and others suggest that a detrimental effect of propofol (mediated through STAT5 inhibition) may also have made a contribution to the findings. Paul S. Pagel, MD, PhDAnesthesia ServiceClement J. Zablocki Veterans Affairs Medical CenterMilwaukee, Wisconsin[email protected] George J. Crystal, PhDDepartment of AnesthesiologyThe University of Illinois College of MedicineChicago, Illinois" @default.
• W2806500511 created "2018-06-13" @default.
• W2806500511 creator A5015027315 @default.
• W2806500511 creator A5080741758 @default.
• W2806500511 date "2018-08-01" @default.
• W2806500511 modified "2023-09-26" @default.
• W2806500511 title "Propofol and Remote Ischemic Preconditioning" @default.
• W2806500511 cites W1824177875 @default.
• W2806500511 cites W2103606060 @default.
• W2806500511 cites W2766306028 @default.
• W2806500511 cites W2780901361 @default.
• W2806500511 doi "https://doi.org/10.1213/ane.0000000000003519" @default.
• W2806500511 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29878943" @default.
• W2806500511 hasPublicationYear "2018" @default.
• W2806500511 type Work @default.
• W2806500511 sameAs 2806500511 @default.
• W2806500511 citedByCount "2" @default.
• W2806500511 countsByYear W28065005112021 @default.
• W2806500511 countsByYear W28065005112023 @default.
• W2806500511 crossrefType "journal-article" @default.
• W2806500511 hasAuthorship W2806500511A5015027315 @default.
• W2806500511 hasAuthorship W2806500511A5080741758 @default.
• W2806500511 hasBestOaLocation W28065005111 @default.
• W2806500511 hasConcept C164705383 @default.
• W2806500511 hasConcept C2776277131 @default.
• W2806500511 hasConcept C2777019824 @default.
• W2806500511 hasConcept C2778162923 @default.
• W2806500511 hasConcept C2778891214 @default.
• W2806500511 hasConcept C2779311647 @default.
• W2806500511 hasConcept C2780393670 @default.
• W2806500511 hasConcept C2781453256 @default.
• W2806500511 hasConcept C42219234 @default.
• W2806500511 hasConcept C541997718 @default.
• W2806500511 hasConcept C71924100 @default.
• W2806500511 hasConceptScore W2806500511C164705383 @default.
• W2806500511 hasConceptScore W2806500511C2776277131 @default.
• W2806500511 hasConceptScore W2806500511C2777019824 @default.
• W2806500511 hasConceptScore W2806500511C2778162923 @default.
• W2806500511 hasConceptScore W2806500511C2778891214 @default.
• W2806500511 hasConceptScore W2806500511C2779311647 @default.
• W2806500511 hasConceptScore W2806500511C2780393670 @default.
• W2806500511 hasConceptScore W2806500511C2781453256 @default.
• W2806500511 hasConceptScore W2806500511C42219234 @default.
• W2806500511 hasConceptScore W2806500511C541997718 @default.
• W2806500511 hasConceptScore W2806500511C71924100 @default.
• W2806500511 hasIssue "2" @default.
• W2806500511 hasLocation W28065005111 @default.
• W2806500511 hasLocation W28065005112 @default.
• W2806500511 hasLocation W28065005113 @default.
• W2806500511 hasOpenAccess W2806500511 @default.
• W2806500511 hasPrimaryLocation W28065005111 @default.
• W2806500511 hasRelatedWork W2116791450 @default.
• W2806500511 hasRelatedWork W2373170717 @default.
• W2806500511 hasRelatedWork W2381135487 @default.
• W2806500511 hasRelatedWork W2392517620 @default.
• W2806500511 hasRelatedWork W2806500511 @default.
• W2806500511 hasRelatedWork W3011271570 @default.
• W2806500511 hasRelatedWork W3029295735 @default.
• W2806500511 hasRelatedWork W3032418202 @default.
• W2806500511 hasRelatedWork W3096723657 @default.
• W2806500511 hasRelatedWork W4308408559 @default.
• W2806500511 hasVolume "127" @default.
• W2806500511 isParatext "false" @default.
• W2806500511 isRetracted "false" @default.
• W2806500511 magId "2806500511" @default.
• W2806500511 workType "article" @default.