FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2806516516> ?p ?o ?g. }

• W2806516516 abstract "Leishmania infantum is the causative agent of human visceral leishmaniasis (VL) and sporadic human cutaneous leishmaniasis (CL) in the Mediterranean region. The genetic variation of the Leishmania parasites may result in different phenotypes that can be associated with the geographical distribution and diversity of the clinical manifestations. The main objective of this study was to explore the genetic polymorphism in L. infantum isolates from human and animal hosts in different regions of Morocco. The intraspecific genetic variability of 40 Moroccan L. infantum MON-1 strains isolated from patients with VL (n = 31) and CL (n = 2) and from dogs (n = 7) was evaluated by PCR-RFLP of nagt, a single-copy gene encoding N-acetylglucosamine-1-phosphate transferase. For a more complete analysis of L. infantum polymorphism, we included the restriction patterns of nagt from 17 strains available in the literature and patterns determined by in-silico digestion of three sequences from the GenBank database. Moroccan L. infantum strains presented a certain level of genetic diversity and six distinct nagt-RFLP genotypes were identified. Three of the six genotypes were exclusively identified in the Moroccan population of L. infantum: variant M1 (15%), variant M2 (7.5%), and variant M3 (2.5%). The most common genotype (65%), variant 2 (2.5%), and variant 4 (7.5%), were previously described in several countries with endemic leishmaniasis. Phylogenetic analysis segregated our L. infantum population into two distinct clusters, whereas variant M2 was clearly distinguished from both cluster I and cluster II. This distribution highlights the degree of genetic variability among the Moroccan L. infantum population. The nagt PCR-RFLP method presented here showed an important genetic heterogeneity among Moroccan L. infantum strains isolated from human and canine reservoirs with 6 genotypes identified. Three of the six Moroccan nagt genotypes, have not been previously described and support the particular genetic diversity of the Moroccan L. infantum population reported in other studies." @default.
• W2806516516 created "2018-06-13" @default.
• W2806516516 creator A5000749189 @default.
• W2806516516 creator A5010591478 @default.
• W2806516516 creator A5036903319 @default.
• W2806516516 creator A5077167525 @default.
• W2806516516 date "2018-06-14" @default.
• W2806516516 modified "2023-10-16" @default.
• W2806516516 title "Genetic polymorphism in Leishmania infantum isolates from human and animals determined by nagt PCR-RFLP" @default.
• W2806516516 cites W1528934273 @default.
• W2806516516 cites W1979516926 @default.
• W2806516516 cites W1982045986 @default.
• W2806516516 cites W1983245570 @default.
• W2806516516 cites W1995384431 @default.
• W2806516516 cites W1998580220 @default.
• W2806516516 cites W2017795378 @default.
• W2806516516 cites W2037329917 @default.
• W2806516516 cites W2037718800 @default.
• W2806516516 cites W2051992968 @default.
• W2806516516 cites W2054092280 @default.
• W2806516516 cites W2054378009 @default.
• W2806516516 cites W2056798455 @default.
• W2806516516 cites W2065972580 @default.
• W2806516516 cites W2067696605 @default.
• W2806516516 cites W2076287232 @default.
• W2806516516 cites W2084934898 @default.
• W2806516516 cites W2089043384 @default.
• W2806516516 cites W2090391739 @default.
• W2806516516 cites W2097590400 @default.
• W2806516516 cites W2098466396 @default.
• W2806516516 cites W2106872016 @default.
• W2806516516 cites W2112241796 @default.
• W2806516516 cites W2113019075 @default.
• W2806516516 cites W2132199935 @default.
• W2806516516 cites W2137301752 @default.
• W2806516516 cites W2143441336 @default.
• W2806516516 cites W2147711588 @default.
• W2806516516 cites W2147931192 @default.
• W2806516516 cites W2167448454 @default.
• W2806516516 cites W2171388951 @default.
• W2806516516 cites W2378548465 @default.
• W2806516516 cites W2541306836 @default.
• W2806516516 cites W2588147074 @default.
• W2806516516 cites W75373324 @default.
• W2806516516 doi "https://doi.org/10.1186/s40249-018-0439-y" @default.
• W2806516516 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6001066" @default.
• W2806516516 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29898776" @default.
• W2806516516 hasPublicationYear "2018" @default.
• W2806516516 type Work @default.
• W2806516516 sameAs 2806516516 @default.
• W2806516516 citedByCount "7" @default.
• W2806516516 countsByYear W28065165162019 @default.
• W2806516516 countsByYear W28065165162020 @default.
• W2806516516 countsByYear W28065165162021 @default.
• W2806516516 countsByYear W28065165162022 @default.
• W2806516516 countsByYear W28065165162023 @default.
• W2806516516 crossrefType "journal-article" @default.
• W2806516516 hasAuthorship W2806516516A5000749189 @default.
• W2806516516 hasAuthorship W2806516516A5010591478 @default.
• W2806516516 hasAuthorship W2806516516A5036903319 @default.
• W2806516516 hasAuthorship W2806516516A5077167525 @default.
• W2806516516 hasBestOaLocation W28065165161 @default.
• W2806516516 hasConcept C104317684 @default.
• W2806516516 hasConcept C135763542 @default.
• W2806516516 hasConcept C168007829 @default.
• W2806516516 hasConcept C172777353 @default.
• W2806516516 hasConcept C2776555147 @default.
• W2806516516 hasConcept C2778689377 @default.
• W2806516516 hasConcept C2781257258 @default.
• W2806516516 hasConcept C2908647359 @default.
• W2806516516 hasConcept C54355233 @default.
• W2806516516 hasConcept C68873052 @default.
• W2806516516 hasConcept C71924100 @default.
• W2806516516 hasConcept C81977670 @default.
• W2806516516 hasConcept C86803240 @default.
• W2806516516 hasConcept C99454951 @default.
• W2806516516 hasConceptScore W2806516516C104317684 @default.
• W2806516516 hasConceptScore W2806516516C135763542 @default.
• W2806516516 hasConceptScore W2806516516C168007829 @default.
• W2806516516 hasConceptScore W2806516516C172777353 @default.
• W2806516516 hasConceptScore W2806516516C2776555147 @default.
• W2806516516 hasConceptScore W2806516516C2778689377 @default.
• W2806516516 hasConceptScore W2806516516C2781257258 @default.
• W2806516516 hasConceptScore W2806516516C2908647359 @default.
• W2806516516 hasConceptScore W2806516516C54355233 @default.
• W2806516516 hasConceptScore W2806516516C68873052 @default.
• W2806516516 hasConceptScore W2806516516C71924100 @default.
• W2806516516 hasConceptScore W2806516516C81977670 @default.
• W2806516516 hasConceptScore W2806516516C86803240 @default.
• W2806516516 hasConceptScore W2806516516C99454951 @default.
• W2806516516 hasFunder F4320307853 @default.
• W2806516516 hasIssue "1" @default.
• W2806516516 hasLocation W28065165161 @default.
• W2806516516 hasLocation W28065165162 @default.
• W2806516516 hasLocation W28065165163 @default.
• W2806516516 hasLocation W28065165164 @default.
• W2806516516 hasOpenAccess W2806516516 @default.
• W2806516516 hasPrimaryLocation W28065165161 @default.
• W2806516516 hasRelatedWork W1589657991 @default.
• W2806516516 hasRelatedWork W1970784326 @default.

• next