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• W2806516908 abstract "Summary Bacterial cells take a variable lag time and maintain a multi-drug tolerant non-growing state before resuming growth when encountering growth-supportive conditions. Some of them exhibit an extraordinarily long lag, as pathogenic persisters do. It remains unknown on what determines lag time duration. Here, we unveiled a subcellular structure, termed quiescent body, that is formed in bacterial cells entering non-growing state and sequesters selected proteins essential for cell growth. Their formation occurs progressively in each cell and heterogeneously among individual cells. They only dissolve in re-growing cells to release proteins for immediate re-functioning when conditions become fit. Quiescent body, whose degree of formation is highly correlated with duration of lag time or level of antibiotic tolerance, apparently functions as a biological timer for bacterial growth resumption. Further, suppressing their formation, which directly relies on cellular respiration complexes, or promoting their dissolution might be a viable strategy to eradicate persisters." @default.
• W2806516908 created "2018-06-13" @default.
• W2806516908 creator A5018596386 @default.
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• W2806516908 date "2017-02-10" @default.
• W2806516908 modified "2023-10-17" @default.
• W2806516908 title "Quiescent Body as a Reversible Subcellular Structure Formed in Non-growing Bacterial Cells" @default.
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• W2806516908 doi "https://doi.org/10.1101/107466" @default.
• W2806516908 hasPublicationYear "2017" @default.
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