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- W280652810 abstract "Abstract An unusual case of erythropoietic porphyria with a severe hemolytic component and thrombocytopenia has been presented. The relationship between the porphyria and the thrombocytopenia, although unclear, showed definite evidence of persistent megakaryocytic hypoplasia. Additional information emphasizing the severity and chronicity of the anemic process included elevated F and A2 hemoglobins, hyperferremia and extramedullary hematopoiesis. The nature of the hemolytic process appeared to be intracorpuscular and not correctible by normal plasma, glucose or ATP. The abnormal in vitro hemolysis, coupled with the appearance of the abnormal nucleated and mature red cells, are suggestive of the defect in heme synthesis seen in some of the hypochromic hypersideremic anemias. A description of therapeutic attempts as well as the appearance of a folate deficiency are included in the report." @default.
- W280652810 created "2016-06-24" @default.
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- W280652810 date "1964-06-01" @default.
- W280652810 modified "2023-09-30" @default.
- W280652810 title "Hematologic Studies on Erythropoietic Porphyria: A New Case with Severe Hemolysis, Chronic Thrombocytopenia, and Folic Acid Deficiency" @default.
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- W280652810 doi "https://doi.org/10.1182/blood.v23.6.762.762" @default.
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