FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2806543204> ?p ?o ?g. }

• W2806543204 endingPage "838" @default.
• W2806543204 startingPage "829" @default.
• W2806543204 abstract "Oral squamous cell carcinoma (OSCC) is the most common malignancy of oral cavity. Despite advances in therapeutic approaches, the 5-year survival rate for oral cancer has not improved in the last three decades. Therefore, new molecular targets for early diagnosis and treatment of OSCC are needed. In the present study, we focused on the enzyme nicotinamide N-methyltransferase (NNMT). We have previously shown that enzyme expression is upregulated in OSCC and NNMT knockdown in PE/CA PJ-15 cells significantly decreased cell growth in vitro and tumorigenicity in vivo. To further explore the role of the enzyme in oral cancer cell metabolism, HSC-2 cells were transfected with the NNMT expression vector (pcDNA3-NNMT) and the effect of enzyme upregulation on cell proliferation was evaluated by MTT assay. Subsequently, we investigated at molecular level the role of NNMT on apoptosis and cell proliferation, by exploring the expression of β-catenin, survivin, and Ki-67 by real-time PCR. Moreover, we performed immunohistochemistry on 20 OSCC tissue samples to explore the expression level of NNMT and survivin ΔEx3 isoform. Enzyme upregulation significantly increased cell growth in vitro. Moreover, a positive correlation between NNMT and survivin ΔEx3 isoform expression levels was found both in HSC-2 cells and in OSCC tissue samples. Taken together, our results indicate a possible involvement of NNMT in the proliferation and tumorigenic capacity of OSCC cells and seem to suggest that the enzyme could represent a potential target for the treatment of oral cancer. The involvement of NNMT in cell growth and anti-apoptotic mechanisms seems to suggest that this enzyme could be a new therapeutic target to improve the survival of OSCC patients." @default.
• W2806543204 created "2018-06-13" @default.
• W2806543204 creator A5018631492 @default.
• W2806543204 creator A5021978069 @default.
• W2806543204 creator A5026300777 @default.
• W2806543204 creator A5034336346 @default.
• W2806543204 creator A5036140082 @default.
• W2806543204 creator A5045815050 @default.
• W2806543204 creator A5053084731 @default.
• W2806543204 creator A5057895298 @default.
• W2806543204 creator A5066720467 @default.
• W2806543204 creator A5083650903 @default.
• W2806543204 date "2018-06-07" @default.
• W2806543204 modified "2023-09-25" @default.
• W2806543204 title "Overexpression of nicotinamide N-methyltransferase in HSC-2 OSCC cell line: effect on apoptosis and cell proliferation" @default.
• W2806543204 cites W1526965676 @default.
• W2806543204 cites W1612393989 @default.
• W2806543204 cites W1970602320 @default.
• W2806543204 cites W1971992755 @default.
• W2806543204 cites W1972350308 @default.
• W2806543204 cites W1972754687 @default.
• W2806543204 cites W1976616566 @default.
• W2806543204 cites W1983312081 @default.
• W2806543204 cites W1990456983 @default.
• W2806543204 cites W1991601678 @default.
• W2806543204 cites W2005791991 @default.
• W2806543204 cites W2010831478 @default.
• W2806543204 cites W2015805627 @default.
• W2806543204 cites W2016081624 @default.
• W2806543204 cites W2025027059 @default.
• W2806543204 cites W2027431501 @default.
• W2806543204 cites W2041384561 @default.
• W2806543204 cites W2042144015 @default.
• W2806543204 cites W2043535031 @default.
• W2806543204 cites W2053844022 @default.
• W2806543204 cites W2064403984 @default.
• W2806543204 cites W2081275593 @default.
• W2806543204 cites W2088512187 @default.
• W2806543204 cites W2091605002 @default.
• W2806543204 cites W2104160333 @default.
• W2806543204 cites W2113773963 @default.
• W2806543204 cites W2131146282 @default.
• W2806543204 cites W2166841784 @default.
• W2806543204 cites W2320365161 @default.
• W2806543204 cites W2411428762 @default.
• W2806543204 cites W4293247451 @default.
• W2806543204 doi "https://doi.org/10.1007/s00784-018-2497-8" @default.
• W2806543204 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29882109" @default.
• W2806543204 hasPublicationYear "2018" @default.
• W2806543204 type Work @default.
• W2806543204 sameAs 2806543204 @default.
• W2806543204 citedByCount "28" @default.
• W2806543204 countsByYear W28065432042019 @default.
• W2806543204 countsByYear W28065432042020 @default.
• W2806543204 countsByYear W28065432042021 @default.
• W2806543204 countsByYear W28065432042022 @default.
• W2806543204 countsByYear W28065432042023 @default.
• W2806543204 crossrefType "journal-article" @default.
• W2806543204 hasAuthorship W2806543204A5018631492 @default.
• W2806543204 hasAuthorship W2806543204A5021978069 @default.
• W2806543204 hasAuthorship W2806543204A5026300777 @default.
• W2806543204 hasAuthorship W2806543204A5034336346 @default.
• W2806543204 hasAuthorship W2806543204A5036140082 @default.
• W2806543204 hasAuthorship W2806543204A5045815050 @default.
• W2806543204 hasAuthorship W2806543204A5053084731 @default.
• W2806543204 hasAuthorship W2806543204A5057895298 @default.
• W2806543204 hasAuthorship W2806543204A5066720467 @default.
• W2806543204 hasAuthorship W2806543204A5083650903 @default.
• W2806543204 hasBestOaLocation W28065432042 @default.
• W2806543204 hasConcept C104317684 @default.
• W2806543204 hasConcept C127561419 @default.
• W2806543204 hasConcept C1491633281 @default.
• W2806543204 hasConcept C190283241 @default.
• W2806543204 hasConcept C2775975398 @default.
• W2806543204 hasConcept C502942594 @default.
• W2806543204 hasConcept C54355233 @default.
• W2806543204 hasConcept C55493867 @default.
• W2806543204 hasConcept C62112901 @default.
• W2806543204 hasConcept C81885089 @default.
• W2806543204 hasConcept C86803240 @default.
• W2806543204 hasConceptScore W2806543204C104317684 @default.
• W2806543204 hasConceptScore W2806543204C127561419 @default.
• W2806543204 hasConceptScore W2806543204C1491633281 @default.
• W2806543204 hasConceptScore W2806543204C190283241 @default.
• W2806543204 hasConceptScore W2806543204C2775975398 @default.
• W2806543204 hasConceptScore W2806543204C502942594 @default.
• W2806543204 hasConceptScore W2806543204C54355233 @default.
• W2806543204 hasConceptScore W2806543204C55493867 @default.
• W2806543204 hasConceptScore W2806543204C62112901 @default.
• W2806543204 hasConceptScore W2806543204C81885089 @default.
• W2806543204 hasConceptScore W2806543204C86803240 @default.
• W2806543204 hasIssue "2" @default.
• W2806543204 hasLocation W28065432041 @default.
• W2806543204 hasLocation W28065432042 @default.
• W2806543204 hasOpenAccess W2806543204 @default.
• W2806543204 hasPrimaryLocation W28065432041 @default.
• W2806543204 hasRelatedWork W2031056725 @default.
• W2806543204 hasRelatedWork W2064698074 @default.

• next