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• W2806548502 abstract "Virus-like Particles in Vaccine Development Production of complex virus-like particles in insect cellsFabiana Fernandes, Ana P Teixeira, Nuno Carinhas, Manuel JT Carrondo & Paula M AlvesFabiana FernandesFabiana Fernandes is a PhD student at the Animal Cell Technology (ACT) Unit of the Instituto de Biologia Experimental e Tecnológica (IBET) and Instituto de Tecnologia Química e Biológica (ITQB)- Universidade Nova de Lisboa (UNL), Oeiras, Portugal. Her PhD project focuses on insect cell line development through site-specific integration and application for the production of complex proteins.Search for more papers by this author, Ana P TeixeiraAna P Teixeira is a senior researcher at the ACT Unit of IBET and ITQB-UNL and her main research focus is on the application of systems and synthetic biology tools to understand and optimize cellular processes.Search for more papers by this author, Nuno CarinhasNuno Carinhas holds a PhD degree in biotechnology from UNL. He is a postdoctoral fellow at the ACT Unit of IBET and ITQB-UNL and his current work focuses on the application of systems biology tools to optimize cellular processes.Search for more papers by this author, Manuel JT CarrondoManuel JT Carrondo is a full Professor of Chemical and Biochemical Engineering at Faculdade de Ciências e Tecnologia, UNL. He is Director, Founder and former CEO of IBET (Oeiras, Portugal). His research activities are focused on the integration of upstream and downstream processes and mathematical tools geared towards applications.Search for more papers by this author & Paula M AlvesPaula M Alves is Chief Executive Officer of IBET, invited Professor at Faculdade de Ciências e Tecnologia, UNL, and Director of the ACT Unit, IBET and ITQB-UNL. Her research activities are focused on understanding cell metabolism to improve the efficiency of bioprocesses for complex biopharmaceuticals and developing new technologies for preclinical research.Search for more papers by this authorPublished Online:30 Jan 2014https://doi.org/10.2217/fmeb2013.13.67AboutSectionsView ArticleView Full TextPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack Citations ShareShare onFacebookTwitterLinkedInReddit View chapterAbstract: Virus-like particles (VLPs) are multiprotein structures that resemble the conformation of native viruses but lack a viral genome, potentiating their application as safer and cheaper vaccines. The production of VLPs has been strongly linked with the use of insect cells and the baculovirus expression vector system, especially those particles composed of two or more structural viral proteins. In fact, this expression platform has been extensively improved over the years to address the challenges of coexpression of multiple proteins and their proper assembly into complexes in the same cell. Herein, the role of insect cell technology in the development and production of complex VLPs will be overviewed. Recent achievements, current bottlenecks and future trends are also highlighted. References1 Kost TA , Condreay JP , Jarvis DL . Baculovirus as versatile vectors for protein expression in insect and mammalian cells . Nat. Biotechnol. 23 (5) , 567 – 575 (2005) . Crossref, Medline, CAS, Google Scholar2 Rhiel M , Mitchell-Logean CM , Murhammer DW . Comparison of Trichoplusia ni BTI-Tn-5B1-4 (High Five) and Spodoptera frugiperda Sf-9 insect cell line metabolism in suspension cultures . Biotechnol. Bioeng. 55 (6) , 909 – 920 (1997) . Crossref, Medline, CAS, Google Scholar3 Roldao A , Mellado MC , Castilho LR , Carrondo MJ , Alves PM . Virus-like particles in vaccine development . 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