Matches in SemOpenAlex for { <https://semopenalex.org/work/W2806565547> ?p ?o ?g. }
- W2806565547 abstract "Abstract Oxidative stress is known to be associated with various age-related diseases. D-galactose (D-gal) has been considered a senescent model which induces oxidative stress response resulting in memory dysfunction. Pyrroloquinoline quinone (PQQ) is a redox cofactor which is found in various foods. In our previous study, we found that PQQ may be converted into a derivative by binding with amino acid, which is beneficial to several pathological processes. In this study, we found a beneficial glutamate mixture which may diminish neurotoxicity by oxidative stress in D-gal induced mouse. Our results showed that PQQ may influence the generation of proinflammatory mediators, including cytokines and prostaglandins during aging process. D-gal-induced mouse showed increased MDA and ROS levels, and decreased T-AOC activities in the hippocampus, these changes were reversed by PQQ supplementation. Furthermore, PQQ statistically enhanced Superoxide Dismutase SOD2 mRNA expression. PQQ could ameliorate the memory deficits and neurotoxicity induced by D-gal via binding with excess glutamate, which provide a link between glutamate-mediated neurotoxicity, inflammation and oxidative stress. In addition, PQQ reduced the up-regulated expression of p-Akt by D-gal and maintained the activity of GSK-3β, resulting in a down-regulation of p-Tau level in hippocampus. PQQ modulated memory ability partly via Akt/GSK-3β pathway." @default.
- W2806565547 created "2018-06-13" @default.
- W2806565547 creator A5004104004 @default.
- W2806565547 creator A5009004976 @default.
- W2806565547 creator A5019450539 @default.
- W2806565547 creator A5020720471 @default.
- W2806565547 creator A5048905952 @default.
- W2806565547 creator A5078069277 @default.
- W2806565547 creator A5084121229 @default.
- W2806565547 date "2018-06-11" @default.
- W2806565547 modified "2023-10-10" @default.
- W2806565547 title "PQQ ameliorates D-galactose induced cognitive impairments by reducing glutamate neurotoxicity via the GSK-3β/Akt signaling pathway in mouse" @default.
- W2806565547 cites W1487155952 @default.
- W2806565547 cites W1494360569 @default.
- W2806565547 cites W1514768249 @default.
- W2806565547 cites W1533853049 @default.
- W2806565547 cites W1535426243 @default.
- W2806565547 cites W1536172939 @default.
- W2806565547 cites W1542215809 @default.
- W2806565547 cites W1545941184 @default.
- W2806565547 cites W1546975896 @default.
- W2806565547 cites W1551313718 @default.
- W2806565547 cites W1584535802 @default.
- W2806565547 cites W1601027696 @default.
- W2806565547 cites W1883382918 @default.
- W2806565547 cites W1909841186 @default.
- W2806565547 cites W1938199221 @default.
- W2806565547 cites W1957525376 @default.
- W2806565547 cites W1963901478 @default.
- W2806565547 cites W1968362444 @default.
- W2806565547 cites W1973473665 @default.
- W2806565547 cites W1981787630 @default.
- W2806565547 cites W1982961937 @default.
- W2806565547 cites W1983055247 @default.
- W2806565547 cites W1984891090 @default.
- W2806565547 cites W1988726352 @default.
- W2806565547 cites W1989036097 @default.
- W2806565547 cites W1990553465 @default.
- W2806565547 cites W1991857339 @default.
- W2806565547 cites W1991882458 @default.
- W2806565547 cites W1996065546 @default.
- W2806565547 cites W1999399730 @default.
- W2806565547 cites W2000609186 @default.
- W2806565547 cites W2002977156 @default.
- W2806565547 cites W2005592457 @default.
- W2806565547 cites W2006423078 @default.
- W2806565547 cites W2008481778 @default.
- W2806565547 cites W2011567936 @default.
- W2806565547 cites W2014007422 @default.
- W2806565547 cites W2015055265 @default.
- W2806565547 cites W2017202952 @default.
- W2806565547 cites W2017824709 @default.
- W2806565547 cites W2020812118 @default.
- W2806565547 cites W2023677185 @default.
- W2806565547 cites W2024149978 @default.
- W2806565547 cites W2024387421 @default.
- W2806565547 cites W2027042725 @default.
- W2806565547 cites W2027183895 @default.
- W2806565547 cites W2029742967 @default.
- W2806565547 cites W2030234189 @default.
- W2806565547 cites W2032706712 @default.
- W2806565547 cites W2034152593 @default.
- W2806565547 cites W2035376760 @default.
- W2806565547 cites W2035575344 @default.
- W2806565547 cites W2042090087 @default.
- W2806565547 cites W2045601200 @default.
- W2806565547 cites W2059867409 @default.
- W2806565547 cites W2060345192 @default.
- W2806565547 cites W2060867589 @default.
- W2806565547 cites W2063087581 @default.
- W2806565547 cites W2064854739 @default.
- W2806565547 cites W2066234282 @default.
- W2806565547 cites W2069386764 @default.
- W2806565547 cites W2076661189 @default.
- W2806565547 cites W2080718980 @default.
- W2806565547 cites W2082402714 @default.
- W2806565547 cites W2082429191 @default.
- W2806565547 cites W2082474912 @default.
- W2806565547 cites W2085850488 @default.
- W2806565547 cites W2086655930 @default.
- W2806565547 cites W2087187579 @default.
- W2806565547 cites W2087572489 @default.
- W2806565547 cites W2090263578 @default.
- W2806565547 cites W2092538255 @default.
- W2806565547 cites W2094177807 @default.
- W2806565547 cites W2094836461 @default.
- W2806565547 cites W2097693778 @default.
- W2806565547 cites W2113688455 @default.
- W2806565547 cites W2114736131 @default.
- W2806565547 cites W2123197349 @default.
- W2806565547 cites W2127903316 @default.
- W2806565547 cites W2129224791 @default.
- W2806565547 cites W2135955660 @default.
- W2806565547 cites W2137749693 @default.
- W2806565547 cites W2147282637 @default.
- W2806565547 cites W2152165298 @default.
- W2806565547 cites W2165263556 @default.
- W2806565547 cites W2168237098 @default.
- W2806565547 cites W2234380999 @default.
- W2806565547 cites W2236194147 @default.