FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2806572083> ?p ?o ?g. }

• W2806572083 endingPage "777" @default.
• W2806572083 startingPage "767" @default.
• W2806572083 abstract "Although the anticancer properties of oligomeric proanthocyanidins (OPCs) from grape seeds have been well recognized, the molecular mechanisms by which they exert anticancer effects are poorly understood. In this study, through comprehensive RNA-sequencing-based gene expression profiling in multiple colorectal cancer cell lines, we for the first time illuminate the genome-wide effects of OPCs from grape seeds in colorectal cancer. Our data revealed that OPCs affect several key cancer-associated genes. In particular, genes involved in cell cycle and DNA replication were most significantly and consistently altered by OPCs across multiple cell lines. Intriguingly, our in vivo experiments showed that OPCs were significantly more potent at decreasing xenograft tumor growth compared with the unfractionated grape seed extract (GSE) that includes the larger polymers of proanthocyanidins. These findings were further confirmed in colorectal cancer patient-derived organoids, wherein OPCs more potently inhibited the formation of organoids compared with GSE. Furthermore, we validated alteration of cell cycle and DNA replication-associated genes in cancer cell lines, mice xenografts as well as patient-derived organoids. Overall, this study provides an unbiased and comprehensive look at the mechanisms by which OPCs exert anticancer properties in colorectal cancer." @default.
• W2806572083 created "2018-06-13" @default.
• W2806572083 creator A5011450428 @default.
• W2806572083 creator A5013049956 @default.
• W2806572083 creator A5019440060 @default.
• W2806572083 creator A5021571935 @default.
• W2806572083 creator A5071604865 @default.
• W2806572083 creator A5073355341 @default.
• W2806572083 creator A5080837446 @default.
• W2806572083 date "2018-04-19" @default.
• W2806572083 modified "2023-10-17" @default.
• W2806572083 title "Mechanistic insights into anticancer properties of oligomeric proanthocyanidins from grape seeds in colorectal cancer" @default.
• W2806572083 cites W1149292194 @default.
• W2806572083 cites W1976333120 @default.
• W2806572083 cites W1979475230 @default.
• W2806572083 cites W1979679866 @default.
• W2806572083 cites W2003138919 @default.
• W2806572083 cites W2021910621 @default.
• W2806572083 cites W2026214591 @default.
• W2806572083 cites W2028714796 @default.
• W2806572083 cites W2034269086 @default.
• W2806572083 cites W2052891178 @default.
• W2806572083 cites W2053232746 @default.
• W2806572083 cites W2067101386 @default.
• W2806572083 cites W2067856799 @default.
• W2806572083 cites W2072966091 @default.
• W2806572083 cites W2075379076 @default.
• W2806572083 cites W2089453670 @default.
• W2806572083 cites W2092119381 @default.
• W2806572083 cites W2094219478 @default.
• W2806572083 cites W2096465161 @default.
• W2806572083 cites W2096639977 @default.
• W2806572083 cites W2102278945 @default.
• W2806572083 cites W2105677187 @default.
• W2806572083 cites W2108234281 @default.
• W2806572083 cites W2121413434 @default.
• W2806572083 cites W2134061119 @default.
• W2806572083 cites W2134526812 @default.
• W2806572083 cites W2136443800 @default.
• W2806572083 cites W2141630197 @default.
• W2806572083 cites W2143926065 @default.
• W2806572083 cites W2144953421 @default.
• W2806572083 cites W2149895103 @default.
• W2806572083 cites W2158419579 @default.
• W2806572083 cites W2160635124 @default.
• W2806572083 cites W2162651347 @default.
• W2806572083 cites W2179438025 @default.
• W2806572083 cites W2188090437 @default.
• W2806572083 cites W2274087348 @default.
• W2806572083 cites W2282335838 @default.
• W2806572083 cites W2339902666 @default.
• W2806572083 cites W2401521092 @default.
• W2806572083 cites W2523125049 @default.
• W2806572083 cites W2555526827 @default.
• W2806572083 cites W2604997718 @default.
• W2806572083 cites W2619317414 @default.
• W2806572083 cites W2735468413 @default.
• W2806572083 cites W2752493454 @default.
• W2806572083 cites W2753171732 @default.
• W2806572083 cites W2758351006 @default.
• W2806572083 cites W2764313231 @default.
• W2806572083 cites W2982196494 @default.
• W2806572083 cites W4240564608 @default.
• W2806572083 doi "https://doi.org/10.1093/carcin/bgy034" @default.
• W2806572083 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5972632" @default.
• W2806572083 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29684110" @default.
• W2806572083 hasPublicationYear "2018" @default.
• W2806572083 type Work @default.
• W2806572083 sameAs 2806572083 @default.
• W2806572083 citedByCount "36" @default.
• W2806572083 countsByYear W28065720832018 @default.
• W2806572083 countsByYear W28065720832019 @default.
• W2806572083 countsByYear W28065720832020 @default.
• W2806572083 countsByYear W28065720832021 @default.
• W2806572083 countsByYear W28065720832022 @default.
• W2806572083 countsByYear W28065720832023 @default.
• W2806572083 crossrefType "journal-article" @default.
• W2806572083 hasAuthorship W2806572083A5011450428 @default.
• W2806572083 hasAuthorship W2806572083A5013049956 @default.
• W2806572083 hasAuthorship W2806572083A5019440060 @default.
• W2806572083 hasAuthorship W2806572083A5021571935 @default.
• W2806572083 hasAuthorship W2806572083A5071604865 @default.
• W2806572083 hasAuthorship W2806572083A5073355341 @default.
• W2806572083 hasAuthorship W2806572083A5080837446 @default.
• W2806572083 hasBestOaLocation W28065720831 @default.
• W2806572083 hasConcept C104317684 @default.
• W2806572083 hasConcept C121608353 @default.
• W2806572083 hasConcept C142724271 @default.
• W2806572083 hasConcept C1491633281 @default.
• W2806572083 hasConcept C204787440 @default.
• W2806572083 hasConcept C207001950 @default.
• W2806572083 hasConcept C2776971262 @default.
• W2806572083 hasConcept C2778004101 @default.
• W2806572083 hasConcept C29537977 @default.
• W2806572083 hasConcept C502942594 @default.
• W2806572083 hasConcept C526805850 @default.
• W2806572083 hasConcept C54355233 @default.
• W2806572083 hasConcept C55493867 @default.

• next