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• W2806575796 abstract "DNA makes RNA makes protein. After transcription, mRNAs undergo a series of intertwining processes to be finally translated into functional proteins. The posttranscriptional regulation (PTR) provides cells an extended option to fine-tune their proteomes. To meet the demands of complex organism development and the appropriate response to environmental stimuli, every step in these processes needs to be finely regulated. Moreover, changes in these regulatory processes are important driving forces underlying the evolution of phenotypic differences across different species. The major PTR mechanisms discussed in this review include the regulation of splicing, polyadenylation, decay, and translation. For alternative splicing and polyadenylation, we mainly discuss their evolutionary dynamics and the genetic changes underlying the regulatory differences in cis-elements versus trans-factors. For mRNA decay and translation, which, together with transcription, determine the cellular RNA or protein abundance, we focus our discussion on how their divergence coordinates with transcriptional changes to shape the evolution of gene expression. Then to highlight the importance of PTR in the evolution of higher complexity, we focus on their roles in two major phenomena during eukaryotic evolution: the evolution of multicellularity and the division of labor between different cell types and tissues; and the emergence of diverse, often highly specialized individual phenotypes, especially those concerning behavior in eusocial insects. This article is categorized under: RNA Evolution and Genomics > RNA and Ribonucleoprotein Evolution Translation > Translation Regulation RNA Processing > Splicing Regulation/Alternative Splicing." @default.
• W2806575796 created "2018-06-13" @default.
• W2806575796 creator A5017541508 @default.
• W2806575796 creator A5025493439 @default.
• W2806575796 creator A5030668248 @default.
• W2806575796 creator A5037696066 @default.
• W2806575796 creator A5052798638 @default.
• W2806575796 date "2018-05-31" @default.
• W2806575796 modified "2023-10-12" @default.
• W2806575796 title "The evolution of posttranscriptional regulation" @default.
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