Matches in SemOpenAlex for { <https://semopenalex.org/work/W2806576072> ?p ?o ?g. }
- W2806576072 endingPage "e1007101" @default.
- W2806576072 startingPage "e1007101" @default.
- W2806576072 abstract "Trypanosoma brucei undergoes life cycle form transitions from trypomastigotes to epimastigotes in the insect vector by re-positioning the mitochondrial genome and re-locating the flagellum and flagellum-associated cytoskeletal structures. The mechanism underlying these dramatic morphology transitions remains poorly understood. Here we report the regulatory role of the orphan kinesin KIN-E in controlling trypanosome morphology transitions. KIN-E localizes to the flagellum and is enriched at the flagellar tip, and this localization depends on the C-terminal m-calpain domain III-like domains. Depletion of KIN-E in the trypomastigote form of T. brucei causes major morphology changes and a gradual increase in the level of EP procyclin, generating epimastigote-like cells. Mechanistically, through its C-terminal importin α-like domain, KIN-E targets FLAM3, a flagellar protein involved in morphology transitions, to the flagellum to promote elongation of the flagellum attachment zone and positioning of the flagellum and flagellum-associated cytoskeletal structure, thereby maintaining trypomastigote cell morphology. Our findings suggest that morphology transitions in trypanosomes require KIN-E-mediated transport of FLAM3 to the flagellum." @default.
- W2806576072 created "2018-06-13" @default.
- W2806576072 creator A5013109261 @default.
- W2806576072 creator A5029758151 @default.
- W2806576072 date "2018-05-29" @default.
- W2806576072 modified "2023-09-30" @default.
- W2806576072 title "An orphan kinesin controls trypanosome morphology transitions by targeting FLAM3 to the flagellum" @default.
- W2806576072 cites W1952803246 @default.
- W2806576072 cites W1973767731 @default.
- W2806576072 cites W1976165046 @default.
- W2806576072 cites W1979799765 @default.
- W2806576072 cites W1981240703 @default.
- W2806576072 cites W1995842016 @default.
- W2806576072 cites W1997470658 @default.
- W2806576072 cites W2013465778 @default.
- W2806576072 cites W2013843427 @default.
- W2806576072 cites W2020753655 @default.
- W2806576072 cites W2034413541 @default.
- W2806576072 cites W2040498921 @default.
- W2806576072 cites W2043099314 @default.
- W2806576072 cites W2050270347 @default.
- W2806576072 cites W2062426037 @default.
- W2806576072 cites W2066034930 @default.
- W2806576072 cites W2071546493 @default.
- W2806576072 cites W2072697783 @default.
- W2806576072 cites W2073689323 @default.
- W2806576072 cites W2076993988 @default.
- W2806576072 cites W2085594139 @default.
- W2806576072 cites W2088352540 @default.
- W2806576072 cites W2097126971 @default.
- W2806576072 cites W2100675331 @default.
- W2806576072 cites W2100699372 @default.
- W2806576072 cites W2108555971 @default.
- W2806576072 cites W2116350092 @default.
- W2806576072 cites W2117625958 @default.
- W2806576072 cites W2117626458 @default.
- W2806576072 cites W2120794878 @default.
- W2806576072 cites W2130863567 @default.
- W2806576072 cites W2131533260 @default.
- W2806576072 cites W2131683819 @default.
- W2806576072 cites W2135772180 @default.
- W2806576072 cites W2139547301 @default.
- W2806576072 cites W2142066514 @default.
- W2806576072 cites W2142692601 @default.
- W2806576072 cites W2143414586 @default.
- W2806576072 cites W2149525061 @default.
- W2806576072 cites W2158865733 @default.
- W2806576072 cites W2167595503 @default.
- W2806576072 cites W2247038813 @default.
- W2806576072 cites W2289384645 @default.
- W2806576072 cites W2346539852 @default.
- W2806576072 cites W2361880397 @default.
- W2806576072 cites W2509850786 @default.
- W2806576072 cites W2737719186 @default.
- W2806576072 cites W4232879185 @default.
- W2806576072 cites W924575423 @default.
- W2806576072 doi "https://doi.org/10.1371/journal.ppat.1007101" @default.
- W2806576072 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5993322" @default.
- W2806576072 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29813136" @default.
- W2806576072 hasPublicationYear "2018" @default.
- W2806576072 type Work @default.
- W2806576072 sameAs 2806576072 @default.
- W2806576072 citedByCount "19" @default.
- W2806576072 countsByYear W28065760722020 @default.
- W2806576072 countsByYear W28065760722021 @default.
- W2806576072 countsByYear W28065760722022 @default.
- W2806576072 countsByYear W28065760722023 @default.
- W2806576072 crossrefType "journal-article" @default.
- W2806576072 hasAuthorship W2806576072A5013109261 @default.
- W2806576072 hasAuthorship W2806576072A5029758151 @default.
- W2806576072 hasBestOaLocation W28065760721 @default.
- W2806576072 hasConcept C100094513 @default.
- W2806576072 hasConcept C104317684 @default.
- W2806576072 hasConcept C115811362 @default.
- W2806576072 hasConcept C142669718 @default.
- W2806576072 hasConcept C1491633281 @default.
- W2806576072 hasConcept C2779502636 @default.
- W2806576072 hasConcept C54355233 @default.
- W2806576072 hasConcept C86803240 @default.
- W2806576072 hasConcept C95444343 @default.
- W2806576072 hasConceptScore W2806576072C100094513 @default.
- W2806576072 hasConceptScore W2806576072C104317684 @default.
- W2806576072 hasConceptScore W2806576072C115811362 @default.
- W2806576072 hasConceptScore W2806576072C142669718 @default.
- W2806576072 hasConceptScore W2806576072C1491633281 @default.
- W2806576072 hasConceptScore W2806576072C2779502636 @default.
- W2806576072 hasConceptScore W2806576072C54355233 @default.
- W2806576072 hasConceptScore W2806576072C86803240 @default.
- W2806576072 hasConceptScore W2806576072C95444343 @default.
- W2806576072 hasFunder F4320337355 @default.
- W2806576072 hasIssue "5" @default.
- W2806576072 hasLocation W28065760721 @default.
- W2806576072 hasLocation W28065760722 @default.
- W2806576072 hasLocation W28065760723 @default.
- W2806576072 hasLocation W28065760724 @default.
- W2806576072 hasOpenAccess W2806576072 @default.
- W2806576072 hasPrimaryLocation W28065760721 @default.
- W2806576072 hasRelatedWork W1974483160 @default.