Matches in SemOpenAlex for { <https://semopenalex.org/work/W2806619984> ?p ?o ?g. }
- W2806619984 abstract "RNA-binding proteins are emerging as key regulators of transitions in cell morphology. The RNA-binding motif protein 3 (RBM3) is a cold-inducible RNA-binding protein with broadly relevant roles in cellular protection, and putative functions in cancer and development. Several findings suggest that RBM3 has morphoregulatory functions germane to its roles in these contexts. For example, RBM3 helps maintain the morphological integrity of cell protrusions during cell stress and disease. Moreover, it is highly expressed in migrating neurons of the developing brain and in cancer invadopodia, suggesting roles in migration. We here show that RBM3 regulates cell polarity, spreading and migration. RBM3 was present in spreading initiation centers, filopodia and blebs that formed during cell spreading in cell lines and primary myoblasts. Reducing RBM3 triggered exaggerated spreading, increased RhoA expression, and a loss of polarity that was rescued by Rho kinase inhibition and overexpression of CRMP2. High RBM3 expression enhanced the motility of cells migrating by a mesenchymal mode involving extension of long protrusions, whereas RBM3 knockdown slowed migration, greatly reducing the ability of cells to extend protrusions and impairing multiple processes that require directional migration. These data establish novel functions of RBM3 of potential significance to tissue repair, metastasis and development." @default.
- W2806619984 created "2018-06-13" @default.
- W2806619984 creator A5030557604 @default.
- W2806619984 creator A5050841546 @default.
- W2806619984 creator A5053410060 @default.
- W2806619984 creator A5065218675 @default.
- W2806619984 creator A5067521459 @default.
- W2806619984 creator A5077506318 @default.
- W2806619984 date "2018-05-09" @default.
- W2806619984 modified "2023-10-16" @default.
- W2806619984 title "Morphoregulatory functions of the RNA-binding motif protein 3 in cell spreading, polarity and migration" @default.
- W2806619984 cites W1081310387 @default.
- W2806619984 cites W1530583566 @default.
- W2806619984 cites W155053962 @default.
- W2806619984 cites W1657039782 @default.
- W2806619984 cites W1964586148 @default.
- W2806619984 cites W1966746704 @default.
- W2806619984 cites W1968783143 @default.
- W2806619984 cites W1972789152 @default.
- W2806619984 cites W1973537206 @default.
- W2806619984 cites W1975149361 @default.
- W2806619984 cites W1976674039 @default.
- W2806619984 cites W1979747511 @default.
- W2806619984 cites W1983504654 @default.
- W2806619984 cites W1987575348 @default.
- W2806619984 cites W1987810509 @default.
- W2806619984 cites W1990238882 @default.
- W2806619984 cites W1990786422 @default.
- W2806619984 cites W1991440852 @default.
- W2806619984 cites W1997759588 @default.
- W2806619984 cites W1999088044 @default.
- W2806619984 cites W2000341255 @default.
- W2806619984 cites W2002294970 @default.
- W2806619984 cites W2002595212 @default.
- W2806619984 cites W2005829018 @default.
- W2806619984 cites W2015985931 @default.
- W2806619984 cites W2016333933 @default.
- W2806619984 cites W2017228656 @default.
- W2806619984 cites W2023339355 @default.
- W2806619984 cites W2023435545 @default.
- W2806619984 cites W2025851625 @default.
- W2806619984 cites W2026375024 @default.
- W2806619984 cites W2027864149 @default.
- W2806619984 cites W2027917639 @default.
- W2806619984 cites W2033236032 @default.
- W2806619984 cites W2040413495 @default.
- W2806619984 cites W2043123806 @default.
- W2806619984 cites W2044350998 @default.
- W2806619984 cites W2044409036 @default.
- W2806619984 cites W2046125604 @default.
- W2806619984 cites W2050599411 @default.
- W2806619984 cites W2051157780 @default.
- W2806619984 cites W2054077521 @default.
- W2806619984 cites W2055378695 @default.
- W2806619984 cites W2056170529 @default.
- W2806619984 cites W2056267596 @default.
- W2806619984 cites W2056714949 @default.
- W2806619984 cites W2060907567 @default.
- W2806619984 cites W2062024916 @default.
- W2806619984 cites W2064140502 @default.
- W2806619984 cites W2068465906 @default.
- W2806619984 cites W2068994511 @default.
- W2806619984 cites W2068994675 @default.
- W2806619984 cites W2075596618 @default.
- W2806619984 cites W2077575227 @default.
- W2806619984 cites W2082281812 @default.
- W2806619984 cites W2083543572 @default.
- W2806619984 cites W2087787890 @default.
- W2806619984 cites W2094807296 @default.
- W2806619984 cites W2096048497 @default.
- W2806619984 cites W2098079674 @default.
- W2806619984 cites W2101840523 @default.
- W2806619984 cites W2105720678 @default.
- W2806619984 cites W2108456034 @default.
- W2806619984 cites W2114566013 @default.
- W2806619984 cites W2114997947 @default.
- W2806619984 cites W2118942329 @default.
- W2806619984 cites W2120050676 @default.
- W2806619984 cites W2121074299 @default.
- W2806619984 cites W2122569219 @default.
- W2806619984 cites W2124995438 @default.
- W2806619984 cites W2126103219 @default.
- W2806619984 cites W2126253960 @default.
- W2806619984 cites W2126524543 @default.
- W2806619984 cites W2129926378 @default.
- W2806619984 cites W2130211160 @default.
- W2806619984 cites W2133054656 @default.
- W2806619984 cites W2134217283 @default.
- W2806619984 cites W2134581110 @default.
- W2806619984 cites W2134807132 @default.
- W2806619984 cites W2135737620 @default.
- W2806619984 cites W2138033496 @default.
- W2806619984 cites W2139337976 @default.
- W2806619984 cites W2139927700 @default.
- W2806619984 cites W2142334354 @default.
- W2806619984 cites W2145977550 @default.
- W2806619984 cites W2147889178 @default.
- W2806619984 cites W2150181623 @default.
- W2806619984 cites W2155867724 @default.
- W2806619984 cites W2163113604 @default.