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- W2806621787 abstract "To function in diverse cellular processes, the dynamic properties of microtubules must be tightly regulated. Cellular microtubules are influenced by a multitude of regulatory proteins, but how their activities are spatiotemporally coordinated within the cell, or on specific microtubules, remains mostly obscure. The conserved kinesin-8 motor proteins are important microtubule regulators, and family members from diverse species combine directed motility with the ability to modify microtubule dynamics. Yet how kinesin-8 activities are appropriately deployed in the cellular context is largely unknown. Here we reveal the importance of the nonmotor tail in differentially controlling the physiological functions of the budding yeast kinesin-8, Kip3. We demonstrate that the tailless Kip3 motor domain adequately governs microtubule dynamics at the bud tip to allow spindle positioning in early mitosis. Notably, discrete regions of the tail mediate specific functions of Kip3 on astral and spindle microtubules. The region proximal to the motor domain operates to spatially regulate astral microtubule stability, while the distal tail serves a previously unrecognized role to control the timing of mitotic spindle disassembly. These findings provide insights into how nonmotor tail domains differentially control kinesin functions in cells and the mechanisms that spatiotemporally control the stability of cellular microtubules." @default.
- W2806621787 created "2018-06-13" @default.
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- W2806621787 date "2018-08-01" @default.
- W2806621787 modified "2023-10-14" @default.
- W2806621787 title "Discrete regions of the kinesin-8 Kip3 tail differentially mediate astral microtubule stability and spindle disassembly" @default.
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- W2806621787 doi "https://doi.org/10.1091/mbc.e18-03-0199" @default.
- W2806621787 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6085823" @default.
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