Matches in SemOpenAlex for { <https://semopenalex.org/work/W2806622490> ?p ?o ?g. }
- W2806622490 abstract "Abstract Plants containing aristolochic acids (AA) are nephrotoxins. Glycine N-methyltransferase (GNMT) acts to bind environmental toxins such as benzo(a)pyrene and aflatoxin B1, translocate into nucleus, and alter hepatic metabolism. This study aims to determine the role of GNMT in AA-induced nephropathy. We established an AA nephropathy mouse model and found that AA type I (AAI)-induced nephropathy at a lower concentration in male than in female mice, implying sex differences in AAI resistance. Microarray analysis and AAI-treated mouse models showed that GNMT moderately reduced AAI-induced nephropathy by lowering the upregulated level of NQO1 in male, but significantly improved the nephropathy additionally by increasing Cyp3A44/3A41 in female. The protective effects of GNMT were absent in female GNMT knockout mice, in which re-expression of hepatic GNMT significantly decreased AAI-induced nephropathy. Mechanism-wise, AAI enhanced GNMT nuclear translocation, resulting in GNMT interaction with the promoter region of the genes encoding Nrf2 and CAR/PXR, the transcription factors for NQO1 and CYP3A44/3A41 , respectively. Unlike the preference for Nrf2/NQO1 transcriptions at lower levels of GNMT, overexpression of GNMT preferred CAR/PXR/CYP3A44/3A41 transcriptions and alleviated kidney injury upon AAI treatment. In summary, hepatic GNMT protected mice from AAI nephropathy by enhancing CAR/PXR/CYP3A44/3A41 transcriptions and reducing Nrf2/NQO1 transcriptions." @default.
- W2806622490 created "2018-06-13" @default.
- W2806622490 creator A5007223219 @default.
- W2806622490 creator A5017662619 @default.
- W2806622490 creator A5021865992 @default.
- W2806622490 creator A5026060611 @default.
- W2806622490 creator A5026099931 @default.
- W2806622490 creator A5050237426 @default.
- W2806622490 creator A5061253670 @default.
- W2806622490 creator A5063366408 @default.
- W2806622490 creator A5069188305 @default.
- W2806622490 creator A5071775280 @default.
- W2806622490 creator A5088992624 @default.
- W2806622490 date "2018-05-03" @default.
- W2806622490 modified "2023-10-14" @default.
- W2806622490 title "Glycine N-methyltransferase inhibits aristolochic acid nephropathy by increasing CYP3A44 and decreasing NQO1 expression in female mouse hepatocytes" @default.
- W2806622490 cites W1488195106 @default.
- W2806622490 cites W1499386625 @default.
- W2806622490 cites W1516497807 @default.
- W2806622490 cites W1542378293 @default.
- W2806622490 cites W1913160485 @default.
- W2806622490 cites W1967745325 @default.
- W2806622490 cites W1970086110 @default.
- W2806622490 cites W1973941830 @default.
- W2806622490 cites W1974812668 @default.
- W2806622490 cites W1975296918 @default.
- W2806622490 cites W1976428197 @default.
- W2806622490 cites W1984574841 @default.
- W2806622490 cites W1985418934 @default.
- W2806622490 cites W1988929639 @default.
- W2806622490 cites W1990296956 @default.
- W2806622490 cites W1990825306 @default.
- W2806622490 cites W1994190290 @default.
- W2806622490 cites W1997538585 @default.
- W2806622490 cites W2011669145 @default.
- W2806622490 cites W2014913485 @default.
- W2806622490 cites W2018086514 @default.
- W2806622490 cites W2022350741 @default.
- W2806622490 cites W2025353681 @default.
- W2806622490 cites W2031136406 @default.
- W2806622490 cites W2033089404 @default.
- W2806622490 cites W2035000881 @default.
- W2806622490 cites W2037847893 @default.
- W2806622490 cites W2045318949 @default.
- W2806622490 cites W2050207944 @default.
- W2806622490 cites W2051109194 @default.
- W2806622490 cites W2052762927 @default.
- W2806622490 cites W2056209977 @default.
- W2806622490 cites W2057584124 @default.
- W2806622490 cites W2062050844 @default.
- W2806622490 cites W2067349504 @default.
- W2806622490 cites W2068368133 @default.
- W2806622490 cites W2068401239 @default.
- W2806622490 cites W2068811471 @default.
- W2806622490 cites W2071155661 @default.
- W2806622490 cites W2073741175 @default.
- W2806622490 cites W2077014158 @default.
- W2806622490 cites W2089401171 @default.
- W2806622490 cites W2090024127 @default.
- W2806622490 cites W2090255089 @default.
- W2806622490 cites W2091658923 @default.
- W2806622490 cites W2100204093 @default.
- W2806622490 cites W2111268058 @default.
- W2806622490 cites W2113011757 @default.
- W2806622490 cites W2116416121 @default.
- W2806622490 cites W2117785761 @default.
- W2806622490 cites W2119657975 @default.
- W2806622490 cites W2120221084 @default.
- W2806622490 cites W2121184922 @default.
- W2806622490 cites W2124581521 @default.
- W2806622490 cites W2126347322 @default.
- W2806622490 cites W2153767651 @default.
- W2806622490 cites W2155680682 @default.
- W2806622490 cites W2155882942 @default.
- W2806622490 cites W2158131289 @default.
- W2806622490 cites W2160173410 @default.
- W2806622490 cites W2160601806 @default.
- W2806622490 cites W2162463986 @default.
- W2806622490 cites W2163351755 @default.
- W2806622490 cites W2163483214 @default.
- W2806622490 cites W2169624083 @default.
- W2806622490 cites W2172119486 @default.
- W2806622490 cites W2174094077 @default.
- W2806622490 cites W2255601054 @default.
- W2806622490 cites W2342725977 @default.
- W2806622490 cites W2345371073 @default.
- W2806622490 cites W2405183840 @default.
- W2806622490 cites W2412136682 @default.
- W2806622490 cites W2738415462 @default.
- W2806622490 cites W2765243483 @default.
- W2806622490 cites W3142714722 @default.
- W2806622490 cites W4250685861 @default.
- W2806622490 doi "https://doi.org/10.1038/s41598-018-22298-6" @default.
- W2806622490 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5934382" @default.
- W2806622490 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29725048" @default.
- W2806622490 hasPublicationYear "2018" @default.
- W2806622490 type Work @default.
- W2806622490 sameAs 2806622490 @default.
- W2806622490 citedByCount "10" @default.
- W2806622490 countsByYear W28066224902018 @default.