FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2806631624> ?p ?o ?g. }

• W2806631624 abstract "Abstract To improve the specificity and penetration of anticancer peptides against tumors, in this study, we examined the effects of co-administration of the membrane-active peptide HPRP-A1 and the tumor homing/penetrating peptide iRGD. iRGD peptide is widely recognized as an efficient cell membrane penetration peptide targeting to α v β 3 integrins and neuropilin-1 (NRP-1) receptors, which show high expression in many tumor cells. The anticancer activity, cancer specificity and penetration activity in vitro and in vivo of the co-administered peptides were examined on 2D monolayer cells, 3D multi-cellular spheroids (MCS) and xenograft nude mice. Co-administration of iRGD and HPRP-A1 exhibited stronger anticancer activity and tumor specificity against A549 non-small cell lung cancer cells with NRP-1 receptor overexpression compared with HPRP-A1 alone. A549 cells showed uptake of the peptide combination and destruction of the integrity of the cell membrane, as well as adherence to the mitochondrial net, resulting in induction of apoptosis by a caspase-dependent pathway. The iRGD peptide dramatically increased the penetration depth of HPRP-A1 on A549 MCS and anticancer efficacy in an A549 xenograft mouse model. Our results suggest that the co-administration strategy of anticancer and penetrating peptides could be a potential therapeutic approach for cancer treatment in clinical practice." @default.
• W2806631624 created "2018-06-13" @default.
• W2806631624 creator A5030303113 @default.
• W2806631624 creator A5036894207 @default.
• W2806631624 creator A5061140388 @default.
• W2806631624 creator A5062215362 @default.
• W2806631624 date "2018-02-02" @default.
• W2806631624 modified "2023-10-01" @default.
• W2806631624 title "Co-administration of iRGD with peptide HPRP-A1 to improve anticancer activity and membrane penetrability" @default.
• W2806631624 cites W1558361583 @default.
• W2806631624 cites W1565406437 @default.
• W2806631624 cites W1587050401 @default.
• W2806631624 cites W1799643604 @default.
• W2806631624 cites W1838335582 @default.
• W2806631624 cites W1922109732 @default.
• W2806631624 cites W1963618034 @default.
• W2806631624 cites W1968755198 @default.
• W2806631624 cites W1973742248 @default.
• W2806631624 cites W1978307760 @default.
• W2806631624 cites W1989658253 @default.
• W2806631624 cites W2008456709 @default.
• W2806631624 cites W2031630601 @default.
• W2806631624 cites W2041585886 @default.
• W2806631624 cites W2049097124 @default.
• W2806631624 cites W2051306355 @default.
• W2806631624 cites W2051389534 @default.
• W2806631624 cites W2052261183 @default.
• W2806631624 cites W2052874737 @default.
• W2806631624 cites W2059735139 @default.
• W2806631624 cites W2079142824 @default.
• W2806631624 cites W2084039931 @default.
• W2806631624 cites W2084567900 @default.
• W2806631624 cites W2084587800 @default.
• W2806631624 cites W2093197485 @default.
• W2806631624 cites W2101017584 @default.
• W2806631624 cites W2120203321 @default.
• W2806631624 cites W2123647020 @default.
• W2806631624 cites W2126224226 @default.
• W2806631624 cites W2136908127 @default.
• W2806631624 cites W2141309207 @default.
• W2806631624 cites W2159650080 @default.
• W2806631624 cites W2163326536 @default.
• W2806631624 cites W2165319492 @default.
• W2806631624 cites W2212467263 @default.
• W2806631624 cites W2252428449 @default.
• W2806631624 cites W2271920515 @default.
• W2806631624 cites W2313088239 @default.
• W2806631624 cites W2570451445 @default.
• W2806631624 cites W2587056758 @default.
• W2806631624 cites W2743454697 @default.
• W2806631624 cites W4239658382 @default.
• W2806631624 cites W588492671 @default.
• W2806631624 cites W801576820 @default.
• W2806631624 doi "https://doi.org/10.1038/s41598-018-20715-4" @default.
• W2806631624 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5797073" @default.
• W2806631624 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29396568" @default.
• W2806631624 hasPublicationYear "2018" @default.
• W2806631624 type Work @default.
• W2806631624 sameAs 2806631624 @default.
• W2806631624 citedByCount "36" @default.
• W2806631624 countsByYear W28066316242018 @default.
• W2806631624 countsByYear W28066316242019 @default.
• W2806631624 countsByYear W28066316242020 @default.
• W2806631624 countsByYear W28066316242021 @default.
• W2806631624 countsByYear W28066316242022 @default.
• W2806631624 countsByYear W28066316242023 @default.
• W2806631624 crossrefType "journal-article" @default.
• W2806631624 hasAuthorship W2806631624A5030303113 @default.
• W2806631624 hasAuthorship W2806631624A5036894207 @default.
• W2806631624 hasAuthorship W2806631624A5061140388 @default.
• W2806631624 hasAuthorship W2806631624A5062215362 @default.
• W2806631624 hasBestOaLocation W28066316241 @default.
• W2806631624 hasConcept C121608353 @default.
• W2806631624 hasConcept C1491633281 @default.
• W2806631624 hasConcept C150903083 @default.
• W2806631624 hasConcept C170493617 @default.
• W2806631624 hasConcept C185592680 @default.
• W2806631624 hasConcept C190283241 @default.
• W2806631624 hasConcept C202751555 @default.
• W2806631624 hasConcept C207001950 @default.
• W2806631624 hasConcept C2776929087 @default.
• W2806631624 hasConcept C2778106830 @default.
• W2806631624 hasConcept C2779281246 @default.
• W2806631624 hasConcept C502942594 @default.
• W2806631624 hasConcept C54355233 @default.
• W2806631624 hasConcept C55493867 @default.
• W2806631624 hasConcept C81729549 @default.
• W2806631624 hasConcept C86803240 @default.
• W2806631624 hasConcept C95444343 @default.
• W2806631624 hasConcept C96232424 @default.
• W2806631624 hasConceptScore W2806631624C121608353 @default.
• W2806631624 hasConceptScore W2806631624C1491633281 @default.
• W2806631624 hasConceptScore W2806631624C150903083 @default.
• W2806631624 hasConceptScore W2806631624C170493617 @default.
• W2806631624 hasConceptScore W2806631624C185592680 @default.
• W2806631624 hasConceptScore W2806631624C190283241 @default.
• W2806631624 hasConceptScore W2806631624C202751555 @default.
• W2806631624 hasConceptScore W2806631624C207001950 @default.
• W2806631624 hasConceptScore W2806631624C2776929087 @default.
• W2806631624 hasConceptScore W2806631624C2778106830 @default.

• next