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• W2806639425 abstract "Advances in Asthma Management Individualized treatment for asthmaJames Fingleton & Richard BeasleyJames FingletonJames Fingleton is a physician specialising in respiratory medicine, and Medical Research Fellow at the Medical Research Institute of New Zealand (Wellington, New Zealand). He is currently investigating potential phenotypes of asthma and COPD.Search for more papers by this author & Richard BeasleyRichard Beasley is a physician at Wellington Hospital, Director of the Medical Research Institute of New Zealand and deputy Chair of the Health Research Council of New Zealand (Auckland, New Zealand). He is an Adjunct Professor at the Universities of Canterbury, Otago and Victoria University of Wellington, New Zealand, and Visiting Professor, University of Southampton, UK. His research interests in respiratory medicine are primarily in the fields of epidemiology and clinical management.Search for more papers by this authorPublished Online:1 Feb 2012https://doi.org/10.2217/ebo.11.176AboutSectionsView ArticleView Full TextPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack Citations ShareShare onFacebookTwitterLinkedInReddit View chapterAbstract: Asthma is a heterogeneous disease with variable treatment responses between patients. This chapter explores different ways of approaching the individualized treatment of asthma. Methods for identifying asthma phenotypes are described along with examples of treatment specifically targeted to defined phenotypic groups and discussion of recent advances in the literature. References1 Wenzel SE . Asthma: defining of the persistent adult phenotypes . Lancet 368 (9537) , 804 – 813 (2006) . Crossref, Medline, CAS, Google Scholar2 Weatherall M , Shirtcliffe P , Travers J et al. 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Predicting response to omalizumab, an anti-IgE antibody, in patients with allergic asthma . Chest 125 (4) , 1378 – 1386 (2004) . Crossref, Medline, CAS, Google Scholar13 Nair P , Pizzichini MMM , Kjarsgaard M et al. Mepolizumab for prednisone-dependent asthma with sputum eosinophilia . N. Engl. J. Med. 360 (10) , 985 – 993 (2009) . Crossref, Medline, CAS, Google Scholar14 Haldar P , Brightling CE , Hargadon B et al. Mepolizumab and exacerbations of refractory eosinophilic asthma . N. Engl. J. Med. 360 (10) , 973 – 984 (2009) . Crossref, Medline, CAS, Google Scholar15 Bleecker ER , Nelson HS , Kraft M et al. β2-receptor polymorphisms in patients receiving salmeterol with or without fluticasone propionate . Am. J. Respir. Crit. Care Med. 181 (7) , 676 – 687 (2010) . Crossref, Medline, CAS, Google Scholar16 Lazarus SC , Chinchilli VM , Rollings NJ et al. Smoking affects response to inhaled corticosteroids or leukotriene receptor antagonists in asthma . Am. J. Respir. Crit. Care Med. 175 (8) , 783 – 790 (2007) . Crossref, Medline, CAS, Google ScholarFiguresReferencesRelatedDetails Advances in Asthma ManagementMetrics Downloaded 17 times History Published online 1 February 2012 Published in print January 2012 Information© Future Medicine Ltd© 2012 Future Medicine LtdPDF download" @default.
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