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• W2806642605 abstract "The abnormal expression of miRNAs (miRs) has previously been reported in respiratory syncytial virus (RSV) disease. However, to the best of our knowledge, the expression of miR‑140‑5p in patients with an RSV infection has never been explored. Reverse transcription‑quantitative polymerase chain reaction was performed to analyze the level of miR‑140‑5p in the blood and nasopharyngeal airway samples. ELISAs were performed to determine the levels of tumor necrosis factor α, interleukin (IL)‑1β, IL‑6 and IL‑8. A dual luciferase reporter assay was also performed to investigate the possible target gene of miR‑140‑5p. The results demonstrated that the levels of miR‑140‑5p were significantly decreased in the nasal mucosal and peripheral blood samples of patients with RSV infection. It was also revealed that overexpression of miR‑140‑5p decreased the inflammatory responses, while inhibition of miR‑140‑5p enhanced the inflammatory responses. Additionally, three binding sites of miR‑140‑5p in the 3'untranslated region (UTR) of Toll‑like receptor (TLR)4 were identified and a dual luciferase reporter assay demonstrated that miR‑140‑5p significantly suppressed the relative luciferase activity of pmirGLO‑TLR4‑3'UTR. Furthermore, the level of miR‑140‑5p was shown to be increased following interferon (IFN)α incubation. Notably, inhibition of miR‑140‑5p markedly attenuated IFNα‑mediated downregulation of tumor necrosis factor α, and interleukin‑1β, ‑6 and ‑8 in BEAS‑2B cells. In summary, decreased miR‑140‑5p levels are involved in RSV‑infection diseases primarily through targeting TLR4." @default.
• W2806642605 created "2018-06-13" @default.
• W2806642605 creator A5023874610 @default.
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• W2806642605 date "2018-06-08" @default.
• W2806642605 modified "2023-09-29" @default.
• W2806642605 title "Decreased microRNA‑140‑5p contributes to respiratory syncytial virus disease through targeting Toll‑like receptor 4" @default.
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• W2806642605 doi "https://doi.org/10.3892/etm.2018.6272" @default.
• W2806642605 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6090293" @default.
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• W2806642605 hasPublicationYear "2018" @default.
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