Matches in SemOpenAlex for { <https://semopenalex.org/work/W2806645012> ?p ?o ?g. }
- W2806645012 endingPage "977" @default.
- W2806645012 startingPage "964" @default.
- W2806645012 abstract "In recent years, there has been a revolutionary expansion in technologic advances and therapeutic innovations in cancer medicine. Cancer diagnostics has begun to move away from a sole dependence on direct tumor tissue biopsy for cancer detection, diagnosis, and treatment monitoring. The need for improvement in molecular cancer diagnostics has never been more important, with not only the advent of cancer genomics and genomics-guided precision medicine but also the recent arrival of cancer immunotherapies. Owing to the practical limitations and risks associated with tissue-based biopsy diagnostics, novel noninvasive cancer diagnostics platforms have continued to evolve and expand in recent years. Examples of these platforms include the liquid biopsy, which is used to interrogate ctDNA or circulating tumor cells, proteomics, metabolomics, and exosomes; the urine biopsy, which is used to assay ctDNAs; saliva and stool biopsies, which are used for molecular genomics assays; and the breath biopsy, which measures volatile organic compounds. These next-generation noninvasive molecular diagnostics assays beyond tissues fundamentally transform the potential utilities of cancer diagnostics to enable repeat, prospective, and serial longitudinal “biopsies” to monitor disease response resistance and progression on therapies. Moreover, they allow continual interrogation and molecular in-depth analysis of the evolving tumor’s pan-canceromics under therapeutic stress. These technological and diagnostic advances have already brought about paradigm-changing next-generation cancer therapeutic strategies to enhance overall treatment efficacies. This article reviews the key noninvasive next-generation molecular diagnostics platforms beyond tissues, with emphasis on clinical utilities and applications." @default.
- W2806645012 created "2018-06-13" @default.
- W2806645012 creator A5035198996 @default.
- W2806645012 creator A5039574585 @default.
- W2806645012 creator A5054366510 @default.
- W2806645012 date "2018-05-01" @default.
- W2806645012 modified "2023-10-16" @default.
- W2806645012 title "Next-Generation Novel Noninvasive Cancer Molecular Diagnostics Platforms Beyond Tissues" @default.
- W2806645012 cites W1666636854 @default.
- W2806645012 cites W1857083380 @default.
- W2806645012 cites W1917588793 @default.
- W2806645012 cites W1940241680 @default.
- W2806645012 cites W1940373023 @default.
- W2806645012 cites W1960512949 @default.
- W2806645012 cites W1964079064 @default.
- W2806645012 cites W1964934512 @default.
- W2806645012 cites W1980441757 @default.
- W2806645012 cites W1980462656 @default.
- W2806645012 cites W1993913242 @default.
- W2806645012 cites W1995134833 @default.
- W2806645012 cites W1998960474 @default.
- W2806645012 cites W200091325 @default.
- W2806645012 cites W2016842946 @default.
- W2806645012 cites W2032735323 @default.
- W2806645012 cites W2038989435 @default.
- W2806645012 cites W2039670227 @default.
- W2806645012 cites W2042198997 @default.
- W2806645012 cites W2048541209 @default.
- W2806645012 cites W2050547995 @default.
- W2806645012 cites W2051096017 @default.
- W2806645012 cites W2053961194 @default.
- W2806645012 cites W2061805562 @default.
- W2806645012 cites W2062021371 @default.
- W2806645012 cites W2062984171 @default.
- W2806645012 cites W2068380327 @default.
- W2806645012 cites W2076036054 @default.
- W2806645012 cites W2076753939 @default.
- W2806645012 cites W2080860848 @default.
- W2806645012 cites W2080943203 @default.
- W2806645012 cites W2081124556 @default.
- W2806645012 cites W2083594352 @default.
- W2806645012 cites W2086364184 @default.
- W2806645012 cites W2089899771 @default.
- W2806645012 cites W2097560495 @default.
- W2806645012 cites W2099626022 @default.
- W2806645012 cites W2099828433 @default.
- W2806645012 cites W2103081012 @default.
- W2806645012 cites W2111304055 @default.
- W2806645012 cites W2116483002 @default.
- W2806645012 cites W2124408477 @default.
- W2806645012 cites W2124422993 @default.
- W2806645012 cites W2125299630 @default.
- W2806645012 cites W2127340110 @default.
- W2806645012 cites W2131103345 @default.
- W2806645012 cites W2131256900 @default.
- W2806645012 cites W2138818960 @default.
- W2806645012 cites W2139144040 @default.
- W2806645012 cites W2143253053 @default.
- W2806645012 cites W2154589460 @default.
- W2806645012 cites W2159007127 @default.
- W2806645012 cites W2159024004 @default.
- W2806645012 cites W2159544356 @default.
- W2806645012 cites W2163117853 @default.
- W2806645012 cites W2166779888 @default.
- W2806645012 cites W2168029077 @default.
- W2806645012 cites W2169223304 @default.
- W2806645012 cites W2170599153 @default.
- W2806645012 cites W2176620333 @default.
- W2806645012 cites W2208155662 @default.
- W2806645012 cites W2232253350 @default.
- W2806645012 cites W2235455856 @default.
- W2806645012 cites W224880912 @default.
- W2806645012 cites W2271392525 @default.
- W2806645012 cites W2293363886 @default.
- W2806645012 cites W2296405075 @default.
- W2806645012 cites W2315581823 @default.
- W2806645012 cites W2318433546 @default.
- W2806645012 cites W2322044910 @default.
- W2806645012 cites W2323356988 @default.
- W2806645012 cites W2373239564 @default.
- W2806645012 cites W2400130066 @default.
- W2806645012 cites W2419065358 @default.
- W2806645012 cites W2479380037 @default.
- W2806645012 cites W2479773785 @default.
- W2806645012 cites W2480740794 @default.
- W2806645012 cites W2521526551 @default.
- W2806645012 cites W2523536421 @default.
- W2806645012 cites W2527338356 @default.
- W2806645012 cites W2556988398 @default.
- W2806645012 cites W2559382297 @default.
- W2806645012 cites W2560830801 @default.
- W2806645012 cites W2563204578 @default.
- W2806645012 cites W2570561340 @default.
- W2806645012 cites W2573891764 @default.
- W2806645012 cites W2588207942 @default.
- W2806645012 cites W2589908515 @default.
- W2806645012 cites W2590954301 @default.
- W2806645012 cites W2596349894 @default.