FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2806651744> ?p ?o ?g. }

• W2806651744 endingPage "412" @default.
• W2806651744 startingPage "403" @default.
• W2806651744 abstract "Bile acids exhibit strong antimicrobial activity as natural detergents, and are involved in lipid digestion and absorption. We investigated the mechanism of bile acid adaptation in Lactobacillus gasseri JCM1131T. Exposure to sublethal concentrations of cholic acid (CA), a major bile acid in humans, resulted in development of resistance to otherwise-lethal concentrations of CA by this intestinal lactic acid bacterium. As this adaptation was accompanied by decreased cell-membrane damage, we analyzed the membrane lipid composition of L. gasseri. Although there was no difference in the proportions of glycolipids (~70%) and phospholipids (~20%), adaptation resulted in an increased abundance of long-sugar-chain glycolipids and a 100% increase in cardiolipin (CL) content (to ~50% of phospholipids) at the expense of phosphatidylglycerol (PG). In model vesicles, the resistance of PG vesicles to solubilization by CA increased with increasing CL/PG ratio. Deletion of the two putative CL synthase genes, the products of which are responsible for CL synthesis from PG, decreased the CL content of the mutants, but did not affect their ability to adapt to CA. Exposure to CA restored the CL content of the two single-deletion mutants, likely due to the activities of the remaining CL synthase. In contrast, the CL content of the double-deletion mutant was not restored, and the lipid composition was modified such that PG predominated (~45% of total lipids) at the expense of glycolipids. Therefore, CL plays important roles in bile acid resistance and maintenance of the membrane lipid composition in L. gasseri." @default.
• W2806651744 created "2018-06-13" @default.
• W2806651744 creator A5023025648 @default.
• W2806651744 creator A5027560892 @default.
• W2806651744 creator A5029621386 @default.
• W2806651744 creator A5031838645 @default.
• W2806651744 creator A5039523771 @default.
• W2806651744 creator A5085539789 @default.
• W2806651744 creator A5086037797 @default.
• W2806651744 creator A5088866295 @default.
• W2806651744 date "2019-03-01" @default.
• W2806651744 modified "2023-09-26" @default.
• W2806651744 title "The membrane phospholipid cardiolipin plays a pivotal role in bile acid adaptation by Lactobacillus gasseri JCM1131T" @default.
• W2806651744 cites W1513897103 @default.
• W2806651744 cites W1667649065 @default.
• W2806651744 cites W1831594414 @default.
• W2806651744 cites W1837247962 @default.
• W2806651744 cites W1934130920 @default.
• W2806651744 cites W1943976550 @default.
• W2806651744 cites W1958092051 @default.
• W2806651744 cites W1965148084 @default.
• W2806651744 cites W1973405681 @default.
• W2806651744 cites W1976651965 @default.
• W2806651744 cites W1976957997 @default.
• W2806651744 cites W1980066447 @default.
• W2806651744 cites W2006061929 @default.
• W2806651744 cites W2008326778 @default.
• W2806651744 cites W2011452694 @default.
• W2806651744 cites W2018044881 @default.
• W2806651744 cites W2019630820 @default.
• W2806651744 cites W2027765311 @default.
• W2806651744 cites W2030915307 @default.
• W2806651744 cites W2031304901 @default.
• W2806651744 cites W2032095327 @default.
• W2806651744 cites W2032487332 @default.
• W2806651744 cites W2034395286 @default.
• W2806651744 cites W2036188863 @default.
• W2806651744 cites W2039333719 @default.
• W2806651744 cites W2045866280 @default.
• W2806651744 cites W2048385477 @default.
• W2806651744 cites W2052434060 @default.
• W2806651744 cites W2053558625 @default.
• W2806651744 cites W2060959693 @default.
• W2806651744 cites W2061450617 @default.
• W2806651744 cites W2063133461 @default.
• W2806651744 cites W2069094450 @default.
• W2806651744 cites W2071273298 @default.
• W2806651744 cites W2073860860 @default.
• W2806651744 cites W2077637487 @default.
• W2806651744 cites W2079166934 @default.
• W2806651744 cites W2082715881 @default.
• W2806651744 cites W2088781465 @default.
• W2806651744 cites W2092041008 @default.
• W2806651744 cites W2100494738 @default.
• W2806651744 cites W2102468056 @default.
• W2806651744 cites W2103366497 @default.
• W2806651744 cites W2107062965 @default.
• W2806651744 cites W2107520748 @default.
• W2806651744 cites W2114209806 @default.
• W2806651744 cites W2120137398 @default.
• W2806651744 cites W2123009778 @default.
• W2806651744 cites W2134370618 @default.
• W2806651744 cites W2152311269 @default.
• W2806651744 cites W2157840194 @default.
• W2806651744 cites W2159011007 @default.
• W2806651744 cites W2159848973 @default.
• W2806651744 cites W2167900518 @default.
• W2806651744 cites W2263252624 @default.
• W2806651744 cites W2606135009 @default.
• W2806651744 cites W4214879492 @default.
• W2806651744 cites W1498677124 @default.
• W2806651744 doi "https://doi.org/10.1016/j.bbalip.2018.06.004" @default.
• W2806651744 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29883797" @default.
• W2806651744 hasPublicationYear "2019" @default.
• W2806651744 type Work @default.
• W2806651744 sameAs 2806651744 @default.
• W2806651744 citedByCount "5" @default.
• W2806651744 countsByYear W28066517442021 @default.
• W2806651744 countsByYear W28066517442022 @default.
• W2806651744 countsByYear W28066517442023 @default.
• W2806651744 crossrefType "journal-article" @default.
• W2806651744 hasAuthorship W2806651744A5023025648 @default.
• W2806651744 hasAuthorship W2806651744A5027560892 @default.
• W2806651744 hasAuthorship W2806651744A5029621386 @default.
• W2806651744 hasAuthorship W2806651744A5031838645 @default.
• W2806651744 hasAuthorship W2806651744A5039523771 @default.
• W2806651744 hasAuthorship W2806651744A5085539789 @default.
• W2806651744 hasAuthorship W2806651744A5086037797 @default.
• W2806651744 hasAuthorship W2806651744A5088866295 @default.
• W2806651744 hasConcept C100544194 @default.
• W2806651744 hasConcept C185592680 @default.
• W2806651744 hasConcept C22222904 @default.
• W2806651744 hasConcept C2775900799 @default.
• W2806651744 hasConcept C2776330855 @default.
• W2806651744 hasConcept C2778536940 @default.
• W2806651744 hasConcept C2778918659 @default.
• W2806651744 hasConcept C2779399885 @default.
• W2806651744 hasConcept C2780206646 @default.

• next