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• W2806656298 abstract "Human pancreatic islets containing insulin-secreting β-cells are notoriously heterogeneous in cell composition. Since β-cell failure is the root cause of diabetes, understanding this heterogeneity is of paramount importance. Recent reports have cataloged human islet transcriptome but not compared single β-cells in detail. Here, we scrutinized ex vivo human islet cells from healthy donors and show that they exhibit de-differentiation signatures. Using single-cell gene expression and immunostaining analyses, we found healthy islet cells to contain polyhormonal transcripts, and INS+ cells to express decreased levels of β-cell genes but high levels of progenitor markers. Rare cells that are doubly positive for progenitor markers/exocrine signatures, and endocrine/exocrine hormones were also present. We conclude that ex vivo human islet cells are plastic and can possibly de-/trans-differentiate across pancreatic cell fates, partly accounting for β-cell functional decline once isolated. Therefore, stabilizing β-cell identity upon isolation may improve its functionality." @default.
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• W2806656298 date "2018-02-09" @default.
• W2806656298 modified "2023-10-16" @default.
• W2806656298 title "Single-cell analyses of human islet cells reveal de-differentiation signatures" @default.
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• W2806656298 doi "https://doi.org/10.1038/s41420-017-0014-5" @default.
• W2806656298 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5841351" @default.
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• W2806656298 hasPublicationYear "2018" @default.
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