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- W2806670178 abstract "Physalin B from Physalis angulata L. ( Solanaceae ) is a naturally occurring secosteroid with multiple biological activities. But its anti-inflammatory activity and mechanism remain unclear. Physalin B effects on RAW264.7 macrophages stimulated by lipopolysaccharide (LPS) were observed in this study. The expression and secretion of tumor necrosis factor- α (TNF- α ) and interleukin-6 (IL-6) induced by LPS were significantly inhibited by physalin B. Meanwhile, the NF- κ B nuclear translocation induced by LPS was inhibited by physalin B. The anti-inflammatory effects of physalin B could not be inhibited by mifepristone (RU486), the blocker of glucocorticoid receptor. In conclusion, physalin B can suppress inflammatory response to LPS in macrophages by inhibiting the production of inflammatory cytokines via NF- κ B signaling." @default.
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- W2806670178 date "2018-06-06" @default.
- W2806670178 modified "2023-10-16" @default.
- W2806670178 title "Physalin B Suppresses Inflammatory Response to Lipopolysaccharide in RAW264.7 Cells by Inhibiting NF-κB Signaling" @default.
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- W2806670178 doi "https://doi.org/10.1155/2018/7943140" @default.
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