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• W2806693786 startingPage "1936" @default.
• W2806693786 abstract "Acute myeloid leukemia (AML) is the most common cause of leukemia-related mortality. The combination of cytarabine and anthracycline has been the gold standard of treatment over the past 40 years, but the distribution of the drugs in the body leads to severe adverse effects. Poor prognosis of older patients with AML is the consequence not only of comorbidities, but also of chemoresistance resulting from frequent secondary AML. Numerous strategies using nanotechnologies are in development to improve drug targeting, pharmacokinetics, administration route, chemoresistance, and adverse effects generally observed. Among the four new drugs approved for AML by the US Food and Drug Administration (FDA) in 2017, Vyxeos® is a novel liposomal formulation of historical AML drugs. Here, we review current AML treatments and discuss how the development of new formulations will change the therapeutic armamentarium." @default.
• W2806693786 created "2018-06-13" @default.
• W2806693786 creator A5011803879 @default.
• W2806693786 creator A5014512013 @default.
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• W2806693786 creator A5054163652 @default.
• W2806693786 date "2018-12-01" @default.
• W2806693786 modified "2023-09-26" @default.
• W2806693786 title "Advances in treatment formulations for acute myeloid leukemia" @default.
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