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• W2806716802 abstract "To reappraise the value of electrochemical skin conductance (ESC) measurement by Sudoscan® to assess the distal involvement of small autonomic fibers in familial amyloid polyneuropathy (FAP) due to various transthyretin (TTR) mutations.ESC was measured at both hands and feet in 126 patients with either Val30Met (n = 65) or non-Val30Met (n = 61) TTR mutation. This series included clinically asymptomatic (n = 21) and paucisymptomatic (n = 30) patients, as well as patients with moderate (n = 37) or advanced (n = 38) TTR-FAP.ESC measures did not differ between patients according to the type of TTR variant and were reduced in 24% of clinically asymptomatic patients, 40% of paucisymptomatic patients, 65% of patients with moderate TTR-FAP, and 92% of patients with advanced TTR-FAP. ESC measures were found to correlate with patients' clinical status, especially assessed by the Neuropathy Impairment Score and Karnofsky Performance Status.ESC measures well correlate with the severity of TTR-FAP and could provide early marker of the disease.ESC measures appear to be relevant to evaluate distal autonomic involvement in the context of amyloidosis." @default.
• W2806716802 created "2018-06-13" @default.
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• W2806716802 date "2018-08-01" @default.
• W2806716802 modified "2023-10-02" @default.
• W2806716802 title "The value of electrochemical skin conductance measurement using Sudoscan® in the assessment of patients with familial amyloid polyneuropathy" @default.
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• W2806716802 doi "https://doi.org/10.1016/j.clinph.2018.05.005" @default.
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