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- W2806755227 abstract "Abstract Skin cancer or cutaneous carcinoma, is a pre-eminent global public health problem with no signs of plateauing in its incidence. As the most common treatments for skin cancer, surgical resection inevitably damages a patient’s appearance, and chemotherapy has many side effects. Thus, the main aim of this study was to screen for a cell penetrating peptide (CPP) for the development of a targeting vector for skin cancer. In this study, we identified a CPP with the sequence NRPDSAQFWLHH from a phage displayed peptide library. This CPP targeted the human squamous carcinoma A431 cells through an interaction with the epidermal growth factor receptor (EGFr). Methyl-β-cyclodextrin (MβCD) and chlorpromazine hydrochloride (CPZ) inhibited the internalisation of the CPP into the A431 cells, suggesting the peptide entered the cells via clathrin-dependent endocytosis. The CPP displayed on hepatitis B virus-like nanoparticles (VLNPs) via the nanoglue successfully delivered the nanoparticles into A431 cells. The present study demonstrated that the novel CPP can serve as a ligand to target and deliver VLNPs into skin cancer cells." @default.
- W2806755227 created "2018-06-13" @default.
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- W2806755227 date "2018-05-31" @default.
- W2806755227 modified "2023-09-27" @default.
- W2806755227 title "Targeted Delivery of Cell Penetrating Peptide Virus-like Nanoparticles to Skin Cancer Cells" @default.
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- W2806755227 doi "https://doi.org/10.1038/s41598-018-26749-y" @default.
- W2806755227 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5981617" @default.
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