FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2806805523> ?p ?o ?g. }

• W2806805523 endingPage "557" @default.
• W2806805523 startingPage "549" @default.
• W2806805523 abstract "Tacrolimus, a critical dose drug, is widely used in transplantation. Knowing the contribution of genetic factors, which significantly influence tacrolimus variability, is beneficial in the personalization of its starting dose. The significant impact of CYP3A5*3 polymorphisms on tacrolimus exposure has been reported. Conflicting results of the additional influence of POR*28 polymorphisms on tacrolimus pharmacokinetic interindividual variability have been observed among different populations. The objective of this study was to explore the interaction between POR*28 and CYP3A5*3 polymorphisms and their main effects on tacrolimus trough concentration to dose ratios on day 7 after kidney transplantation.Two hundred sixteen adult kidney transplant recipients participated in this retrospective study. All participants received a twice daily tacrolimus regimen. Blood samples and data were collected on day 7 after transplantation. A 2-way analysis of covariance was performed. Tested covariates were age, hemoglobin, serum albumin, and prednisolone dose.A 2 × 2 analysis of covariance revealed that the interaction between CYP3A5 polymorphisms (CYP3A5 expresser and CYP3A5 nonexpresser) and POR polymorphisms (POR*28 carrier and POR*28 noncarrier) was not significant (F(1, 209) = 2.473, P = 0.117, (Equation is included in full-text article.)= 0.012). The predicted main effect of CYP3A5 and POR polymorphisms was significant (F(1, 209) = 105.565, P < 0.001, (Equation is included in full-text article.)= 0.336 and F(1, 209) = 4.007, P = 0.047, (Equation is included in full-text article.)= 0.019, respectively). Hemoglobin, age, and steroid dose influenced log C0/dose of tacrolimus (F(1, 209) = 20.612, P < 0.001, (Equation is included in full-text article.)= 0.090; F(1, 209) = 14.360, P < 0.001, (Equation is included in full-text article.)= 0.064; and F(1, 209) = 5.512, P = 0.020, (Equation is included in full-text article.)= 0.026, respectively).After adjusting for the influences of hemoglobin, age, and prednisolone dose, significant impacts of the CYP3A5 and POR polymorphisms on tacrolimus exposure were found. The effect of POR*28 and CYP3A5*3 polymorphisms during the very early period after kidney transplantation is independent of each other." @default.
• W2806805523 created "2018-06-13" @default.
• W2806805523 creator A5000269372 @default.
• W2806805523 creator A5034450943 @default.
• W2806805523 creator A5036684033 @default.
• W2806805523 creator A5046891190 @default.
• W2806805523 creator A5048561277 @default.
• W2806805523 creator A5054185800 @default.
• W2806805523 creator A5061751372 @default.
• W2806805523 creator A5072078739 @default.
• W2806805523 creator A5082484762 @default.
• W2806805523 creator A5084766453 @default.
• W2806805523 date "2018-10-01" @default.
• W2806805523 modified "2023-10-01" @default.
• W2806805523 title "Impact of POR and CYP3A5 Polymorphisms on Trough Concentration to Dose Ratio of Tacrolimus in the Early Post-operative Period Following Kidney Transplantation" @default.
• W2806805523 cites W1180197606 @default.
• W2806805523 cites W1499708022 @default.
• W2806805523 cites W1737600104 @default.
• W2806805523 cites W1794101670 @default.
• W2806805523 cites W1865099583 @default.
• W2806805523 cites W1967670996 @default.
• W2806805523 cites W1986080936 @default.
• W2806805523 cites W2006176801 @default.
• W2806805523 cites W2007523308 @default.
• W2806805523 cites W2022581050 @default.
• W2806805523 cites W2026011628 @default.
• W2806805523 cites W2026360416 @default.
• W2806805523 cites W2027774666 @default.
• W2806805523 cites W2033139608 @default.
• W2806805523 cites W2037253825 @default.
• W2806805523 cites W2041808051 @default.
• W2806805523 cites W2044616618 @default.
• W2806805523 cites W2050730569 @default.
• W2806805523 cites W2054166508 @default.
• W2806805523 cites W2056593533 @default.
• W2806805523 cites W2068650301 @default.
• W2806805523 cites W2071072708 @default.
• W2806805523 cites W2076972557 @default.
• W2806805523 cites W2081858766 @default.
• W2806805523 cites W2086034066 @default.
• W2806805523 cites W2087484885 @default.
• W2806805523 cites W2093663919 @default.
• W2806805523 cites W2094260121 @default.
• W2806805523 cites W2109380210 @default.
• W2806805523 cites W2117053752 @default.
• W2806805523 cites W2120817045 @default.
• W2806805523 cites W2126744966 @default.
• W2806805523 cites W2144535667 @default.
• W2806805523 cites W2144956786 @default.
• W2806805523 cites W2164539379 @default.
• W2806805523 cites W2210812892 @default.
• W2806805523 cites W2261282152 @default.
• W2806805523 cites W2317090998 @default.
• W2806805523 cites W2330631272 @default.
• W2806805523 cites W2402766332 @default.
• W2806805523 cites W2605348885 @default.
• W2806805523 cites W2768259672 @default.
• W2806805523 cites W4211117577 @default.
• W2806805523 cites W4211179245 @default.
• W2806805523 doi "https://doi.org/10.1097/ftd.0000000000000542" @default.
• W2806805523 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29878980" @default.
• W2806805523 hasPublicationYear "2018" @default.
• W2806805523 type Work @default.
• W2806805523 sameAs 2806805523 @default.
• W2806805523 citedByCount "14" @default.
• W2806805523 countsByYear W28068055232019 @default.
• W2806805523 countsByYear W28068055232020 @default.
• W2806805523 countsByYear W28068055232021 @default.
• W2806805523 countsByYear W28068055232022 @default.
• W2806805523 countsByYear W28068055232023 @default.
• W2806805523 crossrefType "journal-article" @default.
• W2806805523 hasAuthorship W2806805523A5000269372 @default.
• W2806805523 hasAuthorship W2806805523A5034450943 @default.
• W2806805523 hasAuthorship W2806805523A5036684033 @default.
• W2806805523 hasAuthorship W2806805523A5046891190 @default.
• W2806805523 hasAuthorship W2806805523A5048561277 @default.
• W2806805523 hasAuthorship W2806805523A5054185800 @default.
• W2806805523 hasAuthorship W2806805523A5061751372 @default.
• W2806805523 hasAuthorship W2806805523A5072078739 @default.
• W2806805523 hasAuthorship W2806805523A5082484762 @default.
• W2806805523 hasAuthorship W2806805523A5084766453 @default.
• W2806805523 hasConcept C104317684 @default.
• W2806805523 hasConcept C112705442 @default.
• W2806805523 hasConcept C126322002 @default.
• W2806805523 hasConcept C126894567 @default.
• W2806805523 hasConcept C135763542 @default.
• W2806805523 hasConcept C2776715498 @default.
• W2806805523 hasConcept C2780303639 @default.
• W2806805523 hasConcept C2909675724 @default.
• W2806805523 hasConcept C2911091166 @default.
• W2806805523 hasConcept C31785415 @default.
• W2806805523 hasConcept C54355233 @default.
• W2806805523 hasConcept C71924100 @default.
• W2806805523 hasConcept C86803240 @default.
• W2806805523 hasConcept C90924648 @default.
• W2806805523 hasConcept C92137452 @default.
• W2806805523 hasConcept C98274493 @default.
• W2806805523 hasConceptScore W2806805523C104317684 @default.

• next