FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2806819257> ?p ?o ?g. }

• W2806819257 abstract "Abstract Parallel clinical and preclinical research have begun to illuminate the biological basis of stress-related disorders, including major depression, but translational bridges informing discrete mechanistic targets for intervention are missing. To address this critical need, we used structural MRI in a mouse model and in a large human sample to examine stress effects on brain structure that may be conserved across species. Specifically, we focused on a previously unexplored approach, whole-brain structural covariance, as it reflects synchronized changes in neuroanatomy, potentially due to mutual trophic influences or shared plasticity across regions. Using the unpredictable chronic mild stress (UCMS) paradigm in mouse we first demonstrate that UCMS-induced elevated behavioral emotionality correlates with increased size of the amygdala and other corticolimbic regions. We further identify focal increases in the amygdala’s ‘hubness’ (degree and strength) set against the background of a global stress-related loss of network clustering and modularity. These macroscopic changes are supported on the molecular level by increased postsynaptic density-95 protein in the amygdala, consistent with stress-induced plastic changes and synaptic strengthening. Finally, we provide clinical evidence that strikingly similar structural network reorganization patterns exist in young adults reporting high childhood trauma and increased mood symptoms. Collectively, we provide initial translational evidence for a conserved stress-related increase in amygdala-centered structural synchrony, as measured by enhanced structural covariance, which is paralleled by a decrease in global structural synchrony. This putative trade-off reflected in increased amygdala-centered plastic changes at the expense of global structural dedifferentiation may represent a mechanistic pathway for depression and related psychopathology." @default.
• W2806819257 created "2018-06-13" @default.
• W2806819257 creator A5004477208 @default.
• W2806819257 creator A5005081549 @default.
• W2806819257 creator A5025162351 @default.
• W2806819257 creator A5027215336 @default.
• W2806819257 creator A5046751162 @default.
• W2806819257 creator A5058105019 @default.
• W2806819257 creator A5062228109 @default.
• W2806819257 creator A5062912691 @default.
• W2806819257 creator A5079310882 @default.
• W2806819257 creator A5082357914 @default.
• W2806819257 creator A5087035074 @default.
• W2806819257 date "2018-01-22" @default.
• W2806819257 modified "2023-10-18" @default.
• W2806819257 title "Shifting priorities: highly conserved behavioral and brain network adaptations to chronic stress across species" @default.
• W2806819257 cites W1197974428 @default.
• W2806819257 cites W1485848540 @default.
• W2806819257 cites W1746614065 @default.
• W2806819257 cites W1760839164 @default.
• W2806819257 cites W1869153849 @default.
• W2806819257 cites W1890675559 @default.
• W2806819257 cites W1976392245 @default.
• W2806819257 cites W1978356973 @default.
• W2806819257 cites W1983537704 @default.
• W2806819257 cites W1986779034 @default.
• W2806819257 cites W1988875934 @default.
• W2806819257 cites W1993859837 @default.
• W2806819257 cites W1994950269 @default.
• W2806819257 cites W1996881939 @default.
• W2806819257 cites W1997403846 @default.
• W2806819257 cites W1998628114 @default.
• W2806819257 cites W2008414779 @default.
• W2806819257 cites W2009779345 @default.
• W2806819257 cites W2009782994 @default.
• W2806819257 cites W2011484875 @default.
• W2806819257 cites W2016756702 @default.
• W2806819257 cites W2025595592 @default.
• W2806819257 cites W2026813655 @default.
• W2806819257 cites W2027569333 @default.
• W2806819257 cites W2029769026 @default.
• W2806819257 cites W2030868131 @default.
• W2806819257 cites W2036814814 @default.
• W2806819257 cites W2037462540 @default.
• W2806819257 cites W2037708431 @default.
• W2806819257 cites W2038553037 @default.
• W2806819257 cites W2042349177 @default.
• W2806819257 cites W2044191726 @default.
• W2806819257 cites W2044710410 @default.
• W2806819257 cites W2047277294 @default.
• W2806819257 cites W2048678006 @default.
• W2806819257 cites W2048892587 @default.
• W2806819257 cites W2056035806 @default.
• W2806819257 cites W2057953148 @default.
• W2806819257 cites W2060035717 @default.
• W2806819257 cites W2060926272 @default.
• W2806819257 cites W2061569133 @default.
• W2806819257 cites W2061730652 @default.
• W2806819257 cites W2066457796 @default.
• W2806819257 cites W2066720008 @default.
• W2806819257 cites W2071010598 @default.
• W2806819257 cites W2071392303 @default.
• W2806819257 cites W2078085488 @default.
• W2806819257 cites W2078565912 @default.
• W2806819257 cites W2085105520 @default.
• W2806819257 cites W2086686257 @default.
• W2806819257 cites W2087955490 @default.
• W2806819257 cites W2096887285 @default.
• W2806819257 cites W2100724786 @default.
• W2806819257 cites W2101006267 @default.
• W2806819257 cites W2102048758 @default.
• W2806819257 cites W2105144622 @default.
• W2806819257 cites W2108888119 @default.
• W2806819257 cites W2110747672 @default.
• W2806819257 cites W2115614479 @default.
• W2806819257 cites W2120032880 @default.
• W2806819257 cites W2121184942 @default.
• W2806819257 cites W2121358117 @default.
• W2806819257 cites W2126606094 @default.
• W2806819257 cites W2127722821 @default.
• W2806819257 cites W2129253531 @default.
• W2806819257 cites W2135455833 @default.
• W2806819257 cites W2136403062 @default.
• W2806819257 cites W2137296158 @default.
• W2806819257 cites W2141747860 @default.
• W2806819257 cites W2147047225 @default.
• W2806819257 cites W2157643754 @default.
• W2806819257 cites W2158476113 @default.
• W2806819257 cites W2158553737 @default.
• W2806819257 cites W2160383565 @default.
• W2806819257 cites W2163349072 @default.
• W2806819257 cites W2166370054 @default.
• W2806819257 cites W2167240821 @default.
• W2806819257 cites W2219654235 @default.
• W2806819257 cites W2231709936 @default.
• W2806819257 cites W2252576063 @default.
• W2806819257 cites W322832166 @default.
• W2806819257 cites W4234682840 @default.
• W2806819257 cites W595079019 @default.
• W2806819257 cites W637241509 @default.

• next