FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2806831585> ?p ?o ?g. }

• W2806831585 abstract "Limb ischemia resulting from peripheral vascular disease is a common cause of morbidity. Vessel occlusion limits blood flow, creating a hypoxic environment that damages distal tissue, requiring therapeutic revascularization. Hypoxia-inducible factors (HIFs) are key transcriptional regulators of hypoxic vascular responses, including angiogenesis and arteriogenesis. Despite vascular smooth muscle cells' (VSMCs') importance in vessel integrity, little is known about their functional responses to hypoxia in peripheral vascular disease. This study investigated the role of VSMC HIF in mediating peripheral ischemic responses.We used ArntSMKO mice with smooth muscle-specific deletion of aryl hydrocarbon receptor nuclear translocator (ARNT, HIF-1β), required for HIF transcriptional activity, in a femoral artery ligation model of peripheral vascular disease. ArntSMKO mice exhibit impaired perfusion recovery despite normal collateral vessel dilation and angiogenic capillary responses. Decreased blood flow manifests in extensive tissue damage and hypoxia in ligated limbs of ArntSMKO mice. Furthermore, loss of aryl hydrocarbon receptor nuclear translocator changes the proliferation, migration, and transcriptional profile of cultured VSMCs. ArntSMKO mice display disrupted VSMC morphologic features and wrapping around arterioles and increased vascular permeability linked to decreased local blood flow.Our data demonstrate that traditional vascular remodeling responses are insufficient to provide robust peripheral tissue reperfusion in ArntSMKO mice. In all, this study highlights HIF responses to hypoxia in arteriole VSMCs critical for the phenotypic and functional stability of vessels that aid in the recovery of blood flow in ischemic peripheral tissues." @default.
• W2806831585 created "2018-06-13" @default.
• W2806831585 creator A5003863511 @default.
• W2806831585 creator A5027132159 @default.
• W2806831585 creator A5037448255 @default.
• W2806831585 creator A5043135478 @default.
• W2806831585 creator A5047328345 @default.
• W2806831585 creator A5049645353 @default.
• W2806831585 creator A5079349008 @default.
• W2806831585 creator A5086302566 @default.
• W2806831585 creator A5087527057 @default.
• W2806831585 date "2018-06-05" @default.
• W2806831585 modified "2023-09-27" @default.
• W2806831585 title "Aryl Hydrocarbon Receptor Nuclear Translocator in Vascular Smooth Muscle Cells Is Required for Optimal Peripheral Perfusion Recovery" @default.
• W2806831585 cites W1495287184 @default.
• W2806831585 cites W1512100404 @default.
• W2806831585 cites W1563659068 @default.
• W2806831585 cites W1968596406 @default.
• W2806831585 cites W1972254794 @default.
• W2806831585 cites W1972308621 @default.
• W2806831585 cites W1976933476 @default.
• W2806831585 cites W1978282308 @default.
• W2806831585 cites W1979129486 @default.
• W2806831585 cites W1980111004 @default.
• W2806831585 cites W1984604224 @default.
• W2806831585 cites W1996123980 @default.
• W2806831585 cites W1997508254 @default.
• W2806831585 cites W2002481662 @default.
• W2806831585 cites W2006226224 @default.
• W2806831585 cites W2009589470 @default.
• W2806831585 cites W2014691356 @default.
• W2806831585 cites W2017140065 @default.
• W2806831585 cites W2020277250 @default.
• W2806831585 cites W2021741218 @default.
• W2806831585 cites W2024564719 @default.
• W2806831585 cites W2034822725 @default.
• W2806831585 cites W2035106720 @default.
• W2806831585 cites W2039809334 @default.
• W2806831585 cites W2050291872 @default.
• W2806831585 cites W2052238247 @default.
• W2806831585 cites W2057960696 @default.
• W2806831585 cites W2058381455 @default.
• W2806831585 cites W2063650204 @default.
• W2806831585 cites W2073627122 @default.
• W2806831585 cites W2077714606 @default.
• W2806831585 cites W2080979809 @default.
• W2806831585 cites W2082456219 @default.
• W2806831585 cites W2083308590 @default.
• W2806831585 cites W2088468623 @default.
• W2806831585 cites W2090463590 @default.
• W2806831585 cites W2098972920 @default.
• W2806831585 cites W2100535466 @default.
• W2806831585 cites W2108186386 @default.
• W2806831585 cites W2110101054 @default.
• W2806831585 cites W2114594794 @default.
• W2806831585 cites W2114719275 @default.
• W2806831585 cites W2118803031 @default.
• W2806831585 cites W2120657231 @default.
• W2806831585 cites W2121822802 @default.
• W2806831585 cites W2122606436 @default.
• W2806831585 cites W2122978965 @default.
• W2806831585 cites W2124053736 @default.
• W2806831585 cites W2129978124 @default.
• W2806831585 cites W2131676053 @default.
• W2806831585 cites W2135336701 @default.
• W2806831585 cites W2141159677 @default.
• W2806831585 cites W2145921809 @default.
• W2806831585 cites W2147944062 @default.
• W2806831585 cites W2150343033 @default.
• W2806831585 cites W2150961929 @default.
• W2806831585 cites W2152395959 @default.
• W2806831585 cites W2158207432 @default.
• W2806831585 cites W2160916988 @default.
• W2806831585 cites W2163252729 @default.
• W2806831585 cites W2167105902 @default.
• W2806831585 cites W2255416051 @default.
• W2806831585 cites W2267375983 @default.
• W2806831585 cites W2312765634 @default.
• W2806831585 cites W2511503076 @default.
• W2806831585 cites W2548537359 @default.
• W2806831585 cites W2586758124 @default.
• W2806831585 cites W2587158179 @default.
• W2806831585 cites W2600632060 @default.
• W2806831585 cites W2743752422 @default.
• W2806831585 cites W656326782 @default.
• W2806831585 doi "https://doi.org/10.1161/jaha.118.009205" @default.
• W2806831585 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6015385" @default.
• W2806831585 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29858371" @default.
• W2806831585 hasPublicationYear "2018" @default.
• W2806831585 type Work @default.
• W2806831585 sameAs 2806831585 @default.
• W2806831585 citedByCount "1" @default.
• W2806831585 countsByYear W28068315852021 @default.
• W2806831585 crossrefType "journal-article" @default.
• W2806831585 hasAuthorship W2806831585A5003863511 @default.
• W2806831585 hasAuthorship W2806831585A5027132159 @default.
• W2806831585 hasAuthorship W2806831585A5037448255 @default.
• W2806831585 hasAuthorship W2806831585A5043135478 @default.
• W2806831585 hasAuthorship W2806831585A5047328345 @default.
• W2806831585 hasAuthorship W2806831585A5049645353 @default.

• next