Matches in SemOpenAlex for { <https://semopenalex.org/work/W2806835230> ?p ?o ?g. }
- W2806835230 endingPage "512" @default.
- W2806835230 startingPage "505" @default.
- W2806835230 abstract "Although novel antiepileptic drugs (AEDs) have been recently released, the issue of drug resistance in epileptic patients remains unsolved and largely unpredictable. Areas covered: We aim to assess the clinical impact of genetic variations that may influence the efficacy of medical treatment in epilepsy patients. Indeed, many genes, including genes encoding drug transporters (ABCB1), drug targets (SCN1A), drug-metabolizing enzymes (CYP2C9, CYP2C19), and human leucocyte antigen (HLA) proteins, may regulate the mechanisms of drug resistance in epilepsy. This review specifically focuses on the ABC genes, which encode multidrug resistance-associated proteins (MRPs) and may reduce the blood-brain barrier penetration of anticonvulsant AEDs. Expert opinion: Drug resistance remains a crucial problem in epilepsy patients. Pharmacogenomic studies may improve our understanding of drug responses and drug resistance by exploring the impact of gene variants and predicting drug responses and tolerability." @default.
- W2806835230 created "2018-06-13" @default.
- W2806835230 creator A5014768495 @default.
- W2806835230 creator A5028569424 @default.
- W2806835230 creator A5067012061 @default.
- W2806835230 creator A5088309302 @default.
- W2806835230 date "2018-05-04" @default.
- W2806835230 modified "2023-10-18" @default.
- W2806835230 title "Clinical reappraisal of the influence of drug-transporter polymorphisms in epilepsy" @default.
- W2806835230 cites W1560809604 @default.
- W2806835230 cites W1731775399 @default.
- W2806835230 cites W1920696238 @default.
- W2806835230 cites W1966418641 @default.
- W2806835230 cites W1967278221 @default.
- W2806835230 cites W1967913742 @default.
- W2806835230 cites W1975445668 @default.
- W2806835230 cites W1977595701 @default.
- W2806835230 cites W1982542571 @default.
- W2806835230 cites W1983678363 @default.
- W2806835230 cites W1985531753 @default.
- W2806835230 cites W1986239798 @default.
- W2806835230 cites W1990156650 @default.
- W2806835230 cites W1991283664 @default.
- W2806835230 cites W1994948520 @default.
- W2806835230 cites W1998742400 @default.
- W2806835230 cites W2001097099 @default.
- W2806835230 cites W2005524956 @default.
- W2806835230 cites W2013533336 @default.
- W2806835230 cites W2021489157 @default.
- W2806835230 cites W2021858421 @default.
- W2806835230 cites W2025225413 @default.
- W2806835230 cites W2027177883 @default.
- W2806835230 cites W2029351291 @default.
- W2806835230 cites W2030449842 @default.
- W2806835230 cites W2030655611 @default.
- W2806835230 cites W2032417894 @default.
- W2806835230 cites W2034204487 @default.
- W2806835230 cites W2035149985 @default.
- W2806835230 cites W2040953964 @default.
- W2806835230 cites W2044199354 @default.
- W2806835230 cites W2044429819 @default.
- W2806835230 cites W2046678330 @default.
- W2806835230 cites W2049881004 @default.
- W2806835230 cites W2051229292 @default.
- W2806835230 cites W2054216255 @default.
- W2806835230 cites W2057755081 @default.
- W2806835230 cites W2061230148 @default.
- W2806835230 cites W2063124482 @default.
- W2806835230 cites W2063288921 @default.
- W2806835230 cites W2066313323 @default.
- W2806835230 cites W2075399115 @default.
- W2806835230 cites W2078642000 @default.
- W2806835230 cites W2081281742 @default.
- W2806835230 cites W2082604108 @default.
- W2806835230 cites W2087470654 @default.
- W2806835230 cites W2089164698 @default.
- W2806835230 cites W2092762612 @default.
- W2806835230 cites W2101061157 @default.
- W2806835230 cites W2104290477 @default.
- W2806835230 cites W2110526135 @default.
- W2806835230 cites W2110790042 @default.
- W2806835230 cites W2111814093 @default.
- W2806835230 cites W2115316843 @default.
- W2806835230 cites W2117339170 @default.
- W2806835230 cites W2123347744 @default.
- W2806835230 cites W2126487804 @default.
- W2806835230 cites W2128072709 @default.
- W2806835230 cites W2140127479 @default.
- W2806835230 cites W2141356899 @default.
- W2806835230 cites W2142181855 @default.
- W2806835230 cites W2146913021 @default.
- W2806835230 cites W2147926788 @default.
- W2806835230 cites W2152538429 @default.
- W2806835230 cites W2154708056 @default.
- W2806835230 cites W2157480615 @default.
- W2806835230 cites W2158134221 @default.
- W2806835230 cites W2163031152 @default.
- W2806835230 cites W2164560833 @default.
- W2806835230 cites W2165672869 @default.
- W2806835230 cites W2168578192 @default.
- W2806835230 cites W2169006271 @default.
- W2806835230 cites W2193573329 @default.
- W2806835230 cites W2314748704 @default.
- W2806835230 cites W2329549632 @default.
- W2806835230 cites W2461967281 @default.
- W2806835230 cites W2548159963 @default.
- W2806835230 cites W2588710572 @default.
- W2806835230 cites W4235607015 @default.
- W2806835230 cites W45106411 @default.
- W2806835230 doi "https://doi.org/10.1080/17425255.2018.1473377" @default.
- W2806835230 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29804481" @default.
- W2806835230 hasPublicationYear "2018" @default.
- W2806835230 type Work @default.
- W2806835230 sameAs 2806835230 @default.
- W2806835230 citedByCount "16" @default.
- W2806835230 countsByYear W28068352302018 @default.
- W2806835230 countsByYear W28068352302019 @default.
- W2806835230 countsByYear W28068352302020 @default.