FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2806840107> ?p ?o ?g. }

• W2806840107 endingPage "478" @default.
• W2806840107 startingPage "472" @default.
• W2806840107 abstract "Both the lung and the thymus are vital target organ for pathogens including viruses. The immunoproteasome (i-proteasome) enhances antigen presentation for MHC class I molecules to activate CD8+T lymphocyte. These facilitate antiviral adaptive immune response. Our previous study found that, expression of i-proteasome subunits in porcine lung was altered during normal and inflammatory conditions. To date, the expression of i-proteasome subunits in porcine thymus to viruses has not been investigated. In the present study, LMP2, LMP7, and MECL-1 were cloned, identified and their sequences encoded predicted proteins of 216, 275, and 278 amino acids, respectively. Expression of LMP2, LMP7, and MECL-1, in the cytoplasm and nucleus, was markedly altered in the porcine reproductive and respiratory syndrome virus (PRRSV)-infected lung and thymus. And dendritic cells and epithelial cells readily expressed the i-proteasome subunit LMP2 in the thymus of PRRSV-infected pigs compared to that in mock-infected pigs. Additionally, the in vitro stimulation of a PAM cell line with PolyI:C for 12 and 24 h resulted in increased LMP2, LMP7, and MECL-1 expression. These results suggest a central role for these complexes in the activation of an antiviral immune response in pigs. A better understanding of the role of the i-proteasome in different cell types, tissues, and hosts could improve vaccine design and facilitate the development of effective treatment strategies for viral infections." @default.
• W2806840107 created "2018-06-13" @default.
• W2806840107 creator A5005359731 @default.
• W2806840107 creator A5022637570 @default.
• W2806840107 creator A5026937923 @default.
• W2806840107 creator A5027853439 @default.
• W2806840107 creator A5057055806 @default.
• W2806840107 creator A5069596466 @default.
• W2806840107 creator A5078230028 @default.
• W2806840107 date "2018-08-01" @default.
• W2806840107 modified "2023-09-27" @default.
• W2806840107 title "Anti-viral immune response in the lung and thymus: Molecular characterization and expression analysis of immunoproteasome subunits LMP2, LMP7 and MECL-1 in pigs" @default.
• W2806840107 cites W1418421153 @default.
• W2806840107 cites W1964004941 @default.
• W2806840107 cites W1975460230 @default.
• W2806840107 cites W1978906675 @default.
• W2806840107 cites W1979507139 @default.
• W2806840107 cites W1984295919 @default.
• W2806840107 cites W2006325825 @default.
• W2806840107 cites W2010239849 @default.
• W2806840107 cites W2013064448 @default.
• W2806840107 cites W2020055521 @default.
• W2806840107 cites W2040363409 @default.
• W2806840107 cites W2047280833 @default.
• W2806840107 cites W2058238065 @default.
• W2806840107 cites W2076493816 @default.
• W2806840107 cites W2093270469 @default.
• W2806840107 cites W2095724872 @default.
• W2806840107 cites W2097164847 @default.
• W2806840107 cites W2099781711 @default.
• W2806840107 cites W2139405922 @default.
• W2806840107 cites W2608603280 @default.
• W2806840107 cites W2736860825 @default.
• W2806840107 cites W4313305938 @default.
• W2806840107 doi "https://doi.org/10.1016/j.bbrc.2018.05.190" @default.
• W2806840107 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29856997" @default.
• W2806840107 hasPublicationYear "2018" @default.
• W2806840107 type Work @default.
• W2806840107 sameAs 2806840107 @default.
• W2806840107 citedByCount "4" @default.
• W2806840107 countsByYear W28068401072019 @default.
• W2806840107 countsByYear W28068401072020 @default.
• W2806840107 countsByYear W28068401072021 @default.
• W2806840107 countsByYear W28068401072022 @default.
• W2806840107 crossrefType "journal-article" @default.
• W2806840107 hasAuthorship W2806840107A5005359731 @default.
• W2806840107 hasAuthorship W2806840107A5022637570 @default.
• W2806840107 hasAuthorship W2806840107A5026937923 @default.
• W2806840107 hasAuthorship W2806840107A5027853439 @default.
• W2806840107 hasAuthorship W2806840107A5057055806 @default.
• W2806840107 hasAuthorship W2806840107A5069596466 @default.
• W2806840107 hasAuthorship W2806840107A5078230028 @default.
• W2806840107 hasConcept C104292427 @default.
• W2806840107 hasConcept C104317684 @default.
• W2806840107 hasConcept C153911025 @default.
• W2806840107 hasConcept C154317977 @default.
• W2806840107 hasConcept C159047783 @default.
• W2806840107 hasConcept C167672396 @default.
• W2806840107 hasConcept C170627219 @default.
• W2806840107 hasConcept C190062978 @default.
• W2806840107 hasConcept C202751555 @default.
• W2806840107 hasConcept C203014093 @default.
• W2806840107 hasConcept C207936829 @default.
• W2806840107 hasConcept C2522874641 @default.
• W2806840107 hasConcept C27740335 @default.
• W2806840107 hasConcept C2776090121 @default.
• W2806840107 hasConcept C2779819720 @default.
• W2806840107 hasConcept C55493867 @default.
• W2806840107 hasConcept C83464605 @default.
• W2806840107 hasConcept C86803240 @default.
• W2806840107 hasConcept C8891405 @default.
• W2806840107 hasConcept C95444343 @default.
• W2806840107 hasConceptScore W2806840107C104292427 @default.
• W2806840107 hasConceptScore W2806840107C104317684 @default.
• W2806840107 hasConceptScore W2806840107C153911025 @default.
• W2806840107 hasConceptScore W2806840107C154317977 @default.
• W2806840107 hasConceptScore W2806840107C159047783 @default.
• W2806840107 hasConceptScore W2806840107C167672396 @default.
• W2806840107 hasConceptScore W2806840107C170627219 @default.
• W2806840107 hasConceptScore W2806840107C190062978 @default.
• W2806840107 hasConceptScore W2806840107C202751555 @default.
• W2806840107 hasConceptScore W2806840107C203014093 @default.
• W2806840107 hasConceptScore W2806840107C207936829 @default.
• W2806840107 hasConceptScore W2806840107C2522874641 @default.
• W2806840107 hasConceptScore W2806840107C27740335 @default.
• W2806840107 hasConceptScore W2806840107C2776090121 @default.
• W2806840107 hasConceptScore W2806840107C2779819720 @default.
• W2806840107 hasConceptScore W2806840107C55493867 @default.
• W2806840107 hasConceptScore W2806840107C83464605 @default.
• W2806840107 hasConceptScore W2806840107C86803240 @default.
• W2806840107 hasConceptScore W2806840107C8891405 @default.
• W2806840107 hasConceptScore W2806840107C95444343 @default.
• W2806840107 hasFunder F4320323155 @default.
• W2806840107 hasIssue "4" @default.
• W2806840107 hasLocation W28068401071 @default.
• W2806840107 hasLocation W28068401072 @default.
• W2806840107 hasOpenAccess W2806840107 @default.
• W2806840107 hasPrimaryLocation W28068401071 @default.

• next