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- W2806840149 endingPage "117" @default.
- W2806840149 startingPage "107" @default.
- W2806840149 abstract "A roadblock to successful treatment for anxiety and depression is the high proportion of individuals that do not respond to existing treatments. Different underlying neurobiological mechanisms may drive similar symptoms, so a more personalized approach to treatment could be more successful. There is increasing evidence that sex is an important biological variable modulating efficacy of antidepressants and anxiolytics. We review evidence for sex-specific effects of traditional monoamine based antidepressants and newer pharmaceuticals targeting kappa opioid receptors (KOR), oxytocin receptors (OTR), and N-methyl-D-aspartate receptors (ketamine). In some cases, similar behavioral effects are observed in both sexes while in other cases strong sex-specific effects are observed. Most intriguing are cases such as ketamine which has similar behavioral effects in males and females, perhaps through sex-specific neurobiological mechanisms. These results show how essential it is to include both males and females in both clinical and preclinical evaluations of novel antidepressants and anxiolytics." @default.
- W2806840149 created "2018-06-13" @default.
- W2806840149 creator A5061048719 @default.
- W2806840149 creator A5084947561 @default.
- W2806840149 date "2018-07-01" @default.
- W2806840149 modified "2023-10-12" @default.
- W2806840149 title "The impact of sex as a biological variable in the search for novel antidepressants" @default.
- W2806840149 cites W1067107096 @default.
- W2806840149 cites W1409281047 @default.
- W2806840149 cites W1510078047 @default.
- W2806840149 cites W1529419914 @default.
- W2806840149 cites W1604971537 @default.
- W2806840149 cites W1633497115 @default.
- W2806840149 cites W1671833268 @default.
- W2806840149 cites W1734948187 @default.
- W2806840149 cites W1887417181 @default.
- W2806840149 cites W1948173875 @default.
- W2806840149 cites W1960048350 @default.
- W2806840149 cites W1966194833 @default.
- W2806840149 cites W1966874045 @default.
- W2806840149 cites W1968315111 @default.
- W2806840149 cites W1969010790 @default.
- W2806840149 cites W1969866963 @default.
- W2806840149 cites W1971510748 @default.
- W2806840149 cites W1974370090 @default.
- W2806840149 cites W1976392245 @default.
- W2806840149 cites W1977593923 @default.
- W2806840149 cites W1979031324 @default.
- W2806840149 cites W1981097208 @default.
- W2806840149 cites W1981654563 @default.
- W2806840149 cites W1981899418 @default.
- W2806840149 cites W1981979601 @default.
- W2806840149 cites W1983123817 @default.
- W2806840149 cites W1983754627 @default.
- W2806840149 cites W1989923863 @default.
- W2806840149 cites W1992791641 @default.
- W2806840149 cites W1993399656 @default.
- W2806840149 cites W1994568212 @default.
- W2806840149 cites W1996135092 @default.
- W2806840149 cites W1996515322 @default.
- W2806840149 cites W1996987808 @default.
- W2806840149 cites W1997454271 @default.
- W2806840149 cites W1997538585 @default.
- W2806840149 cites W1998821779 @default.
- W2806840149 cites W1999269819 @default.
- W2806840149 cites W1999646306 @default.
- W2806840149 cites W1999753672 @default.
- W2806840149 cites W2003982930 @default.
- W2806840149 cites W2003986910 @default.
- W2806840149 cites W2005076717 @default.
- W2806840149 cites W2005124365 @default.
- W2806840149 cites W2005501593 @default.
- W2806840149 cites W2007376383 @default.
- W2806840149 cites W2007855905 @default.
- W2806840149 cites W2010158373 @default.
- W2806840149 cites W2010531200 @default.
- W2806840149 cites W2011063704 @default.
- W2806840149 cites W2014163105 @default.
- W2806840149 cites W2017242154 @default.
- W2806840149 cites W2017323063 @default.
- W2806840149 cites W2017876257 @default.
- W2806840149 cites W2021214998 @default.
- W2806840149 cites W2021988264 @default.
- W2806840149 cites W2023081218 @default.
- W2806840149 cites W2023872238 @default.
- W2806840149 cites W2024049038 @default.
- W2806840149 cites W2027431314 @default.
- W2806840149 cites W2028063775 @default.
- W2806840149 cites W2029584624 @default.
- W2806840149 cites W2030902548 @default.
- W2806840149 cites W2031214296 @default.
- W2806840149 cites W2032643119 @default.
- W2806840149 cites W2035587441 @default.
- W2806840149 cites W2038181972 @default.
- W2806840149 cites W2042669554 @default.
- W2806840149 cites W2043184629 @default.
- W2806840149 cites W2046518068 @default.
- W2806840149 cites W2046975053 @default.
- W2806840149 cites W2048175288 @default.
- W2806840149 cites W2049587475 @default.
- W2806840149 cites W2052191286 @default.
- W2806840149 cites W2053972011 @default.
- W2806840149 cites W2057200138 @default.
- W2806840149 cites W2060706252 @default.
- W2806840149 cites W2062102986 @default.
- W2806840149 cites W2062106032 @default.
- W2806840149 cites W2064450732 @default.
- W2806840149 cites W2066823831 @default.
- W2806840149 cites W2069260918 @default.
- W2806840149 cites W2070420735 @default.
- W2806840149 cites W2071721757 @default.
- W2806840149 cites W2071979087 @default.
- W2806840149 cites W2072568231 @default.
- W2806840149 cites W2074135805 @default.
- W2806840149 cites W2078245733 @default.
- W2806840149 cites W2079262367 @default.
- W2806840149 cites W2079355643 @default.
- W2806840149 cites W2080242611 @default.