Matches in SemOpenAlex for { <https://semopenalex.org/work/W2806854027> ?p ?o ?g. }
- W2806854027 endingPage "9097" @default.
- W2806854027 startingPage "9093" @default.
- W2806854027 abstract "Enantioselective functionalizations of unbiased methylene C(sp3 )-H bonds of linear systems by metal insertion are intrinsically challenging and remain a largely unsolved problem. Herein, we report a palladium(II)-catalyzed enantioselective arylation of unbiased methylene β-C(sp3 )-H bonds enabled by the combination of a strongly coordinating bidentate PIP auxiliary with a monodentate chiral phosphoric acid (CPA). The synergistic effect between the PIP auxiliary and the non-C2 -symmetric CPA is crucial for effective stereocontrol. A broad range of aliphatic carboxylic acids and aryl bromides can be used, providing β-arylated aliphatic carboxylic acid derivatives in high yields (up to 96 %) with good enantioselectivities (up to 95:5 e.r.). Notably, this reaction also represents the first palladium(II)-catalyzed enantioselective C-H activation with less reactive and cost-effective aryl bromides as the arylating reagents. Mechanistic studies suggest that a single CPA is involved in the stereodetermining C-H palladation step." @default.
- W2806854027 created "2018-06-13" @default.
- W2806854027 creator A5023509593 @default.
- W2806854027 creator A5048941636 @default.
- W2806854027 creator A5056567982 @default.
- W2806854027 creator A5058718448 @default.
- W2806854027 creator A5061117495 @default.
- W2806854027 creator A5063426419 @default.
- W2806854027 date "2018-06-19" @default.
- W2806854027 modified "2023-09-23" @default.
- W2806854027 title "Palladium(II)-Catalyzed Enantioselective Arylation of Unbiased Methylene C(sp<sup>3</sup> )−H Bonds Enabled by a 2-Pyridinylisopropyl Auxiliary and Chiral Phosphoric Acids" @default.
- W2806854027 cites W1854082529 @default.
- W2806854027 cites W1903659543 @default.
- W2806854027 cites W1956040901 @default.
- W2806854027 cites W1967641329 @default.
- W2806854027 cites W1971273761 @default.
- W2806854027 cites W1974638659 @default.
- W2806854027 cites W1984232099 @default.
- W2806854027 cites W1994390276 @default.
- W2806854027 cites W2000897874 @default.
- W2806854027 cites W2001291798 @default.
- W2806854027 cites W2008199297 @default.
- W2806854027 cites W2033705595 @default.
- W2806854027 cites W2037032992 @default.
- W2806854027 cites W2046348943 @default.
- W2806854027 cites W2061142370 @default.
- W2806854027 cites W2066309940 @default.
- W2806854027 cites W2072171392 @default.
- W2806854027 cites W2072356342 @default.
- W2806854027 cites W2099004477 @default.
- W2806854027 cites W2103259703 @default.
- W2806854027 cites W2109268869 @default.
- W2806854027 cites W2112943497 @default.
- W2806854027 cites W2113280703 @default.
- W2806854027 cites W2115586050 @default.
- W2806854027 cites W2119004319 @default.
- W2806854027 cites W2123458349 @default.
- W2806854027 cites W2125014016 @default.
- W2806854027 cites W2126000622 @default.
- W2806854027 cites W2133275647 @default.
- W2806854027 cites W2152978465 @default.
- W2806854027 cites W2153701075 @default.
- W2806854027 cites W2158930657 @default.
- W2806854027 cites W2165858980 @default.
- W2806854027 cites W2167167027 @default.
- W2806854027 cites W2169228921 @default.
- W2806854027 cites W2227266941 @default.
- W2806854027 cites W2232665245 @default.
- W2806854027 cites W2305289487 @default.
- W2806854027 cites W2308509085 @default.
- W2806854027 cites W2312338337 @default.
- W2806854027 cites W2317020669 @default.
- W2806854027 cites W2322685659 @default.
- W2806854027 cites W2327617209 @default.
- W2806854027 cites W2333335708 @default.
- W2806854027 cites W2515061549 @default.
- W2806854027 cites W2515342784 @default.
- W2806854027 cites W2528441550 @default.
- W2806854027 cites W2529230409 @default.
- W2806854027 cites W2530999578 @default.
- W2806854027 cites W2555942852 @default.
- W2806854027 cites W2557556606 @default.
- W2806854027 cites W2567830583 @default.
- W2806854027 cites W2583627348 @default.
- W2806854027 cites W2588579770 @default.
- W2806854027 cites W2589065087 @default.
- W2806854027 cites W2615334728 @default.
- W2806854027 cites W2745755076 @default.
- W2806854027 cites W2783199949 @default.
- W2806854027 cites W2785449624 @default.
- W2806854027 cites W2787869092 @default.
- W2806854027 cites W4236561413 @default.
- W2806854027 cites W4236727034 @default.
- W2806854027 cites W4241901130 @default.
- W2806854027 cites W4244736186 @default.
- W2806854027 cites W4245527240 @default.
- W2806854027 cites W4248283030 @default.
- W2806854027 cites W4250608952 @default.
- W2806854027 cites W4251169026 @default.
- W2806854027 cites W4252234010 @default.
- W2806854027 cites W4252794137 @default.
- W2806854027 cites W4253538357 @default.
- W2806854027 doi "https://doi.org/10.1002/anie.201804197" @default.
- W2806854027 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29806879" @default.
- W2806854027 hasPublicationYear "2018" @default.
- W2806854027 type Work @default.
- W2806854027 sameAs 2806854027 @default.
- W2806854027 citedByCount "114" @default.
- W2806854027 countsByYear W28068540272018 @default.
- W2806854027 countsByYear W28068540272019 @default.
- W2806854027 countsByYear W28068540272020 @default.
- W2806854027 countsByYear W28068540272021 @default.
- W2806854027 countsByYear W28068540272022 @default.
- W2806854027 countsByYear W28068540272023 @default.
- W2806854027 crossrefType "journal-article" @default.
- W2806854027 hasAuthorship W2806854027A5023509593 @default.
- W2806854027 hasAuthorship W2806854027A5048941636 @default.
- W2806854027 hasAuthorship W2806854027A5056567982 @default.