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• W2806857459 abstract "BackgroundLittle is known about the role of interleukin (IL)-1 in the pathogenesis of cystic fibrosis (CF) lung disease. This study investigated the relationship between IL-1 signalling, neutrophilic inflammation and structural lung changes in children with CF.MethodsBronchoalveolar lavage fluid (BALf) from 102 children with CF were used to determine IL-1α, IL-1β, IL-8 levels and neutrophil elastase (NE) activity, which were then correlated to structural lung changes observed on chest computed tomography (CT) scans.ResultsIL-1α and IL-1β were detectable in BAL in absence of infection, increased in the presence of bacterial infection and correlated with IL-8 (p < 0.0001), neutrophils (p < 0.0001) and NE activity (p < 0.01 and p < 0.001). IL-1α had the strongest association with structural lung disease (p < 0.01) in the absence of infection (uninfected: p < 0.01 vs. infected: p = 0.122).ConclusionOur data associates IL-1α with early structural lung damage in CF and suggests this pathway as a novel anti-inflammatory target." @default.
• W2806857459 created "2018-06-13" @default.
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• W2806857459 date "2018-11-01" @default.
• W2806857459 modified "2023-10-14" @default.
• W2806857459 title "Interleukin-1 is associated with inflammation and structural lung disease in young children with cystic fibrosis" @default.
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• W2806857459 doi "https://doi.org/10.1016/j.jcf.2018.05.006" @default.
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