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- W2806871106 abstract "In situ structural information on molecular machines can be invaluable in understanding their assembly, mechanism and evolution. Here, the use of electron cryotomography (ECT) to obtain significant insights into how an archetypal molecular machine, the bacterial flagellar motor, functions and how it has evolved is described. Over the last decade, studies using a high-throughput, medium-resolution ECT approach combined with genetics, phylogenetic reconstruction and phenotypic analysis have revealed surprising structural diversity in flagellar motors. Variations in the size and the number of torque-generating proteins in the motor visualized for the first time using ECT has shown that these variations have enabled bacteria to adapt their swimming torque to the environment. Much of the structural diversity can be explained in terms of scaffold structures that facilitate the incorporation of additional motor proteins, and more recent studies have begun to infer evolutionary pathways to higher torque-producing motors. This review seeks to highlight how the emerging power of ECT has enabled the inference of ancestral states from various bacterial species towards understanding how, and `why', flagellar motors have evolved from an ancestral motor to a diversity of variants with adapted or modified functions." @default.
- W2806871106 created "2018-06-13" @default.
- W2806871106 creator A5062826378 @default.
- W2806871106 creator A5065575098 @default.
- W2806871106 date "2018-06-01" @default.
- W2806871106 modified "2023-09-29" @default.
- W2806871106 title "Insights into the evolution of bacterial flagellar motors from high-throughput <i>in situ</i> electron cryotomography and subtomogram averaging" @default.
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- W2806871106 doi "https://doi.org/10.1107/s2059798318007945" @default.
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