FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2806928430> ?p ?o ?g. }

• W2806928430 abstract "Myelodysplastic syndromes (MDS) are a heterogeneous group of hematologic neoplasms varying in severity affecting one or more lines of hematopoiesis. Ineffective erythropoiesis results in dysregulation of iron metabolism. Most MDS patients have anemia, and some require regular red blood cell transfusions. These transfusions, in addition to factors of the disease itself, can result in iron overload (IO). Retrospective analyses suggest that MDS patients with IO have reduced overall survival and poorer outcomes following allogeneic stem cell transplant vs. those without IO. Iron chelation therapy (ICT; deferoxamine, deferasirox, or deferiprone) has been used to alleviate IO in other transfusion-dependent hematologic conditions (e.g., thalassemia), but its role in MDS has not been firmly established. A growing body of evidence suggests that ICT in MDS patients is an effective means for reducing transfusional IO and may significantly improve outcomes such as survival. The orally administered iron chelator deferasirox has been widely studied in MDS, and available studies have shown it to be generally well tolerated and effective in reducing IO in this population. The pathophysiology and clinical consequences of IO in MDS, as well as current methods for diagnosing and treating IO in these patients, are discussed." @default.
• W2806928430 created "2018-06-13" @default.
• W2806928430 creator A5062630021 @default.
• W2806928430 creator A5075272187 @default.
• W2806928430 date "2018-06-01" @default.
• W2806928430 modified "2023-10-04" @default.
• W2806928430 title "Iron Overload in Myelodysplastic Syndromes: Pathophysiology, Consequences, Diagnosis, and Treatment" @default.
• W2806928430 cites W1479737129 @default.
• W2806928430 cites W1484640986 @default.
• W2806928430 cites W1510055678 @default.
• W2806928430 cites W1758333280 @default.
• W2806928430 cites W1909939068 @default.
• W2806928430 cites W1926532043 @default.
• W2806928430 cites W1963703308 @default.
• W2806928430 cites W1972140920 @default.
• W2806928430 cites W1974629977 @default.
• W2806928430 cites W1976321261 @default.
• W2806928430 cites W1981353719 @default.
• W2806928430 cites W1990355537 @default.
• W2806928430 cites W2002794485 @default.
• W2806928430 cites W2019321502 @default.
• W2806928430 cites W2023231296 @default.
• W2806928430 cites W2026805835 @default.
• W2806928430 cites W2028813547 @default.
• W2806928430 cites W2040449770 @default.
• W2806928430 cites W2050426026 @default.
• W2806928430 cites W2053771647 @default.
• W2806928430 cites W2061221733 @default.
• W2806928430 cites W2061352340 @default.
• W2806928430 cites W2072228349 @default.
• W2806928430 cites W2074001235 @default.
• W2806928430 cites W2080131381 @default.
• W2806928430 cites W2086820492 @default.
• W2806928430 cites W2094556937 @default.
• W2806928430 cites W2098550012 @default.
• W2806928430 cites W2100714797 @default.
• W2806928430 cites W2106314646 @default.
• W2806928430 cites W2108739937 @default.
• W2806928430 cites W2109076483 @default.
• W2806928430 cites W2116016358 @default.
• W2806928430 cites W2118046222 @default.
• W2806928430 cites W2126125807 @default.
• W2806928430 cites W2138523722 @default.
• W2806928430 cites W2138614889 @default.
• W2806928430 cites W2140559350 @default.
• W2806928430 cites W2150165263 @default.
• W2806928430 cites W2160052344 @default.
• W2806928430 cites W2161342177 @default.
• W2806928430 cites W2171943217 @default.
• W2806928430 cites W2176539120 @default.
• W2806928430 cites W2190900500 @default.
• W2806928430 cites W2260679033 @default.
• W2806928430 cites W2266818917 @default.
• W2806928430 cites W2278976048 @default.
• W2806928430 cites W2291840919 @default.
• W2806928430 cites W2296257365 @default.
• W2806928430 cites W2470713331 @default.
• W2806928430 cites W2513075827 @default.
• W2806928430 cites W2516599519 @default.
• W2806928430 cites W2522975021 @default.
• W2806928430 cites W2585560332 @default.
• W2806928430 cites W2585979817 @default.
• W2806928430 doi "https://doi.org/10.6004/jadpro.2018.9.4.3" @default.
• W2806928430 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6347085" @default.
• W2806928430 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30719392" @default.
• W2806928430 hasPublicationYear "2018" @default.
• W2806928430 type Work @default.
• W2806928430 sameAs 2806928430 @default.
• W2806928430 citedByCount "4" @default.
• W2806928430 countsByYear W28069284302020 @default.
• W2806928430 countsByYear W28069284302021 @default.
• W2806928430 crossrefType "journal-article" @default.
• W2806928430 hasAuthorship W2806928430A5062630021 @default.
• W2806928430 hasAuthorship W2806928430A5075272187 @default.
• W2806928430 hasConcept C126322002 @default.
• W2806928430 hasConcept C177713679 @default.
• W2806928430 hasConcept C2776517179 @default.
• W2806928430 hasConcept C2776672577 @default.
• W2806928430 hasConcept C2777799968 @default.
• W2806928430 hasConcept C2778248108 @default.
• W2806928430 hasConcept C2779134260 @default.
• W2806928430 hasConcept C2779703530 @default.
• W2806928430 hasConcept C2780007613 @default.
• W2806928430 hasConcept C2780817109 @default.
• W2806928430 hasConcept C2780844101 @default.
• W2806928430 hasConcept C2781053155 @default.
• W2806928430 hasConcept C71924100 @default.
• W2806928430 hasConceptScore W2806928430C126322002 @default.
• W2806928430 hasConceptScore W2806928430C177713679 @default.
• W2806928430 hasConceptScore W2806928430C2776517179 @default.
• W2806928430 hasConceptScore W2806928430C2776672577 @default.
• W2806928430 hasConceptScore W2806928430C2777799968 @default.
• W2806928430 hasConceptScore W2806928430C2778248108 @default.
• W2806928430 hasConceptScore W2806928430C2779134260 @default.
• W2806928430 hasConceptScore W2806928430C2779703530 @default.
• W2806928430 hasConceptScore W2806928430C2780007613 @default.
• W2806928430 hasConceptScore W2806928430C2780817109 @default.
• W2806928430 hasConceptScore W2806928430C2780844101 @default.
• W2806928430 hasConceptScore W2806928430C2781053155 @default.
• W2806928430 hasConceptScore W2806928430C71924100 @default.

• next